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- Hedström, Anna, 1983, et al.
(author)
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On the Radical Nature of Iron-Catalyzed Cross-Coupling Reactions
- 2015
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In: Chemistry-a European Journal. - : Wiley. - 0947-6539. ; 21:15, s. 5946-5953
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Journal article (peer-reviewed)abstract
- The radical nature of iron-catalyzed cross-coupling between Grignard reagents and alkyl halides has been studied by using a combination of competitive kinetic experiments and DFT calculations. In contrast to the corresponding coupling with aryl halides, which commences through a classical two-electron oxidative addition/reductive elimination sequence, the presented data suggest that alkyl halides react through an atom-transfer-initiated radical pathway. Furthermore, a general iodine-based quenching methodology was developed to enable the determination of highly accurate concentrations of Grignard reagents, a capability that facilitates and increases the information output of kinetic investigations based on these substrates.
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