| 1. |
- Assenza, Giacomo, et al.
(author)
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White Paper on Industry Experiences in Critical Information Infrastructure Security : A Special Session at CRITIS 2019
- 2020
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In: Critical Information Infrastructures Security14th International Conference, CRITIS 2019. - Cham : Springer. - 9783030376697 - 9783030376703 ; , s. 197-207
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Book chapter (peer-reviewed)abstract
- The security of critical infrastructures is of paramount importance nowadays due to the growing complexity of components and applications. This paper collects the contributions to the industry dissemination session within the 14th International Conference on Critical Information Infrastructures Security (CRITIS 2019). As such, it provides an overview of recent practical experience reports in the field of critical infrastructure protection (CIP), involving major industry players. The set of cases reported in this paper includes the usage of serious gaming for training infrastructure operators, integrated safety and security management in the chemical/process industry, risks related to the cyber-economy for energy suppliers, smart troubleshooting in the Internet of Things (IoT), as well as intrusion detection in power distribution Supervisory Control And Data Acquisition (SCADA). The session has been organized to stimulate an open scientific discussion about industry challenges, open issues and future opportunities in CIP research.
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| 2. |
- Do, Ron, et al.
(author)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Journal article (peer-reviewed)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 3. |
- Reiman, Teemu, et al.
(author)
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Principles of adaptive management in complex safety-critical organizations
- 2015
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In: Safety Science. - : Elsevier BV. - 0925-7535 .- 1879-1042. ; 71, s. 80-92
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Journal article (peer-reviewed)abstract
- This paper contributes to safety management by bringing in ideas from organizational complexity theories. Much of the studies and the literature on organizations as complex adaptive systems have focused on how to produce new innovations or how to increase financial effectiveness. We take the view that safety-critical organizations can be perceived as complex adaptive systems, and we discuss what this means for the management of safety. Our aim is to elaborate on the issue of what kinds of principles the management of safety should be based on in complex adaptive systems. In brief, we suggest that safety management should be adaptive, building on several different principles. Based on literature on complex adaptive systems we first identify the general features of complex adaptive systems, such as self-organizing and non-linearity, which need to be considered in management. Based on the features of complex adaptive systems, we define eight key principles of adaptive safety management and illustrate usefulness of the principles in making sense of the practice of safety management.
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| 4. |
- Willer, Cristen J., et al.
(author)
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Discovery and refinement of loci associated with lipid levels
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
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Journal article (peer-reviewed)abstract
- Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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