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Träfflista för sökning "WFRF:(Hellstrom M) "

Search: WFRF:(Hellstrom M)

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  • Campbell, PJ, et al. (author)
  • Pan-cancer analysis of whole genomes
  • 2020
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
  • Journal article (peer-reviewed)abstract
    • Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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  • Schlegel, C, et al. (author)
  • K-isomers in very neutron-rich nuclei around mass 180
  • 2000
  • In: Physica Scripta. Topical Issues. - 0281-1847. ; T88, s. 72-76
  • Journal article (peer-reviewed)abstract
    • gamma-spectroscopy methods have been used to search for microsecond isomers among the fragmentation products of a 1 GeV/nucleon Pb-208 beam. In particular the population of the known K-pi = 35/2(-) isomer in W-179 has been investigated and several new isomeric decays have been found for neutron rich nuclei in the A approximate to 180-200 mass region. The ground state band of the neutron rich N = 116 system of W-190 has been identified for the first time and we discuss its structure in comparison to neighboring systems.
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  • Result 1-10 of 448
Type of publication
journal article (273)
conference paper (173)
research review (2)
Type of content
peer-reviewed (257)
other academic/artistic (191)
Author/Editor
Hellstrom-Lindberg, ... (204)
Hellstrom, M (92)
Malcovati, L (80)
Fenaux, P (58)
Cazzola, M (57)
Hellstrom, PM (51)
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Bowen, D (48)
Jadersten, M. (48)
Boultwood, J (46)
Pellagatti, A (42)
Sanz, G (40)
Germing, U (40)
Karimi, M (39)
Smith, A (36)
Papaemmanuil, E (35)
de Witte, T (33)
Cermak, J (33)
Symeonidis, A (32)
Jansson, M. (31)
Stauder, R (29)
Giagounidis, A (29)
Tobiasson, M (28)
Della Porta, MG (26)
Holm, MS (23)
Ogawa, S. (21)
Creignou, M (20)
Wainscoat, JS (20)
Dimitriou, M (20)
Killick, S (18)
Mortera-Blanco, T (18)
Tatic, A (18)
Geissel, H. (17)
de Swart, L (17)
Hellstrom-Lindahl, E (16)
Naslund, E (16)
Droste, J (16)
Johansson, H (15)
Campbell, PJ (15)
Vyas, P (15)
Nordberg, A (14)
Nilsson, L. (14)
Platzbecker, U (14)
Beyne-Rauzy, O (14)
Saft, L (14)
Savic, A. (14)
Lordal, M (13)
Gerl, J. (13)
Gorska, M. (13)
van de Loosdrecht, A ... (13)
Dybedal, I (13)
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University
Karolinska Institutet (397)
Uppsala University (38)
Lund University (32)
Linköping University (13)
Chalmers University of Technology (11)
University of Gothenburg (7)
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Umeå University (4)
Royal Institute of Technology (3)
Högskolan Dalarna (2)
Red Cross University College (2)
Örebro University (1)
RISE (1)
Swedish University of Agricultural Sciences (1)
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Language
English (448)
Research subject (UKÄ/SCB)
Medical and Health Sciences (36)
Natural sciences (26)

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