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- Henriksson, G, et al.
(author)
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Expression of P-glycoprotein 170 in nasal mucosa may be increased with topical steroids
- 1997
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In: American journal of rhinology. - : SAGE Publications. - 1050-6586 .- 1539-6290. ; 11:4, s. 317-321
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Journal article (peer-reviewed)abstract
- The synthesis of P-glycoprotein 170 (P-gp), a “multidrug resistance” protein capable of extruding various drugs including 11-OH steroids from human cells, can be upregulated by certain glucocorticosteroids. This study demonstrates the presence of P-gp in the columnar surface epithelium and in glandular acini of healthy nasal mucosa with immunohistochemical technique. Furthermore, nasal polyps from 5 of 17 patients treated with clinical doses of a topical nasal steroid, budesonide, appear to show a stronger staining intensity for P-gp than polyps from 13 untreated patients. This suggests the possibility of local P-gp gene induction by topical glucocorticoid treatment. Upregulation of P-gp synthesis appears as a new possible cause of relative resistance to topical steroid medication in patients with nasal inflammatory disease.
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