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Träfflista för sökning "WFRF:(Herzyk Pawel) "

Search: WFRF:(Herzyk Pawel)

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1.
  • Dalby, Matthew J, et al. (author)
  • Nanomechanotransduction and interphase nuclear organization influence on genomic control.
  • 2007
  • In: Journal of Cellular Biochemistry. - : Wiley. - 0730-2312 .- 1097-4644. ; 102:5, s. 1234-44
  • Journal article (peer-reviewed)abstract
    • The ability of cells to alter their genomic regulation in response to mechanical conditioning or through changes in morphology and the organization of the interphase nuclei are key questions in cell biology. Here, two nanotopographies have been used as a model surfaces to change cell morphology in order to investigate spatial genomic changes within the nuclei of fibroblasts. Initially, centromeres for chromosome pairs were labeled and the average distance on different substrates calculated. Further to this, Affymetrix whole genome GeneChips were used to rank genomic changes in response to topography and plot the whereabouts on the chromosomes these changes were occurring. It was seen that as cell spreading was changed, so were the positions along the chromosomes that gene regulations were being observed. We hypothesize that as changes in cell and thus nuclear morphology occur, that this may alter the probability of transcription through opening or closing areas of the chromosomes to transcription factors.
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2.
  • Wang, Dai, et al. (author)
  • Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds
  • 2011
  • In: Journal of Biological Chemistry. - : American Society for Biochemistry and Molecular Biology. - 0021-9258 .- 1083-351X. ; 286:34, s. 29922-29931
  • Journal article (peer-reviewed)abstract
    • A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide the first identification of bacterial proteins that are targeted by this group of compounds. We provide evidence that their mode of action is likely to result from a synergistic effect arising from a perturbation of the function of several conserved proteins. We also examine the contribution of selected target proteins to the pathogenicity of Yersina pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.
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