| 1. |
- Gielen, Marij, et al.
(author)
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Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies
- 2018
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165. ; 108:3, s. 453-475
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Journal article (peer-reviewed)abstract
- Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ("young": 18-60 y; "middle": 61-75 y; and "old": >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.
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| 2. |
- Rasmussen, Stig HR, et al.
(author)
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Parental transmission and the importance of the (non-causal) effects of education on political engagement: Missing the forest for the trees
- 2023
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In: Social Psychological and Personality Science. - : SAGE Publications. - 1948-5506 .- 1948-5514. ; 14:7, s. 854-864
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Journal article (peer-reviewed)abstract
- By most accounts, an important prerequisite for a well-functioning democracy is engaged citizens. A very prominent explanation of variation in political engagement suggests that parental transmission through socialization accounts for individual-level differences in political engagement. In this paper, we show, using a large Danish twin survey ( N = 2,071), that classic formulations of parental transmission theory can be supplemented by findings from the biopolitics literature, allowing us to disentangle when heritable factors are important and when socialization factors are important predictors of political engagement. We show that as the level of family politicization and consistency increases, the influence of genes decreases. We take this to imply that family socialization can compensate for (genetic) individual differences and foster increased political engagement. By only focusing on the “causal” effect of education, we are missing the forest for the trees.
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