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- Hoa, Hoang Thai, et al.
(author)
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Effects of compounds from physalis angulata on fatty acid synthesis and glucose metabolism in HEPG2 cells via the AMP-activated protein kinase pathway
- 2020
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In: Natural Product Sciences. - 1226-3907. ; 26:3, s. 200-206
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Journal article (peer-reviewed)abstract
- The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.
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| 2. |
- Nguyet, To Thi, et al.
(author)
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Enhanced response characteristics of NO2 gas sensor based on ultrathin SnS2 nanoplates : Experimental and DFT study
- 2024
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In: Sensors and Actuators A-Physical. - : Elsevier. - 0924-4247 .- 1873-3069. ; 373
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Journal article (peer-reviewed)abstract
- Layered-metal dichalcogenides with extraordinary characteristics of vast surface area, tunable bandgap and superior adsorption capability enable the potential for application in gas sensors. However, the synthesis of effective material for enhanced response performance remains a challenge. Herein, we exploited a fascinating sensitivity and selectivity towards NO2 gas detection using SnS2 nanoflakes prepared via the hydrothermal method. SnS2 nanoflakes with a thickness of 25 nm and an average diameter of approximately 500 nm show the potential for the detection of NO2 gas at low concentrations of ppb levels. The sensing properties of the SnS2 sensors were investigated for different concentrations of NO2 at various operating temperatures. The sensor exhibits the highest gas-sensing response of 161 at 250 οC upon exposure to 5 ppm of NO2 gas with fast response and recovery times. In addition, the sensor shows excellent selectivity with a low detection limit of ppb level. The electronic structure and gas-sensing mechanism are elucidated via finding density of states, charge density, and band structure based on DFT study which is calculated by the Vienna ab-initio simulation package (VASP). The considerable small adsorption energy reveals a physisorption of the NO2 molecules on the SnS2 surface (-0.174 eV), indicating the SnS2 nanoflakes are intriguing candidates for the speedy detection of NO2 gas.
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