| 1. |
|
|
| 2. |
- Thompson, Paul M., et al.
(författare)
-
The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
-
Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
-
Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
|
|
| 3. |
|
|
| 4. |
- Wedlund, Cyril Simon, et al.
(författare)
-
Solar wind charge exchange in cometary atmospheres : III. Results from the Rosetta mission to comet 67P/Churyumov-Gerasimenko
- 2019
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 630
-
Tidskriftsartikel (refereegranskat)abstract
- Context. Solar wind charge-changing reactions are of paramount importance to the physico-chemistry of the atmosphere of a comet. The ESA/Rosetta mission to comet 67P/Churyumov-Gerasimenko (67P) provides a unique opportunity to study charge-changing processes in situ.Aims. To understand the role of these reactions in the evolution of the solar wind plasma and interpret the complex in situ measurements made by Rosetta, numerical or analytical models are necessary.Methods. We used an extended analytical formalism describing solar wind charge-changing processes at comets along solar wind streamlines. The model is driven by solar wind ion measurements from the Rosetta Plasma Consortium-Ion Composition Analyser (RPC-ICA) and neutral density observations from the Rosetta Spectrometer for Ion and Neutral Analysis-Comet Pressure Sensor (ROSINA-COPS), as well as by charge-changing cross sections of hydrogen and helium particles in a water gas.Results. A mission-wide overview of charge-changing efficiencies at comet 67P is presented. Electron capture cross sections dominate and favor the production of He and H energetic neutral atoms (ENAs), with fluxes expected to rival those of H+ and He2+ ions.Conclusions. Neutral outgassing rates are retrieved from local RPC-ICA flux measurements and match ROSINA estimates very well throughout the mission. From the model, we find that solar wind charge exchange is unable to fully explain the magnitude of the sharp drop in solar wind ion fluxes observed by Rosetta for heliocentric distances below 2.5 AU. This is likely because the model does not take the relative ion dynamics into account and to a lesser extent because it ignores the formation of bow-shock-like structures upstream of the nucleus. This work also shows that the ionization by solar extreme-ultraviolet radiation and energetic electrons dominates the source of cometary ions, although solar wind contributions may be significant during isolated events.
|
|
| 5. |
|
|
| 6. |
- Aczel, Balazs, et al.
(författare)
-
Consensus-based guidance for conducting and reporting multi-analyst studies
- 2021
-
Ingår i: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Any large dataset can be analyzed in a number of ways, and it is possible that the use of different analysis strategies will lead to different results and conclusions. One way to assess whether the results obtained depend on the analysis strategy chosen is to employ multiple analysts and leave each of them free to follow their own approach. Here, we present consensus-based guidance for conducting and reporting such multi-analyst studies, and we discuss how broader adoption of the multi-analyst approach has the potential to strengthen the robustness of results and conclusions obtained from analyses of datasets in basic and applied research.
|
|
| 7. |
|
|
| 8. |
-
Advances in Pattern-Based Ontology Engineering
- 2021
-
Samlingsverk (redaktörskap) (refereegranskat)abstract
- Ontologies are the corner stone of data modeling and knowledge representation, and engineering an ontology is a complex task in which domain knowledge, ontological accuracy and computational properties need to be carefully balanced. As with any engineering task, the identification and documentation of common patterns is important, and Ontology Design Patterns (ODPs) provide ontology designers with a strong connection to requirements and a better communication of their semantic content and intent.This book, Advances in Pattern-Based Ontology Engineering, contains 23 extended versions of selected papers presented at the annual Workshop on Ontology Design and Patterns (WOP) between 2017 and 2020. This yearly event, which attracts a large number of researchers and professionals in the field of ontology engineering and ontology design patterns, covers issues related to quality aspects of ontology engineering and ODPs for data and knowledge representation, and is usually co-located with the International Semantic Web Conference (ISWC), apart from WOP 2020, which was held virtually due to the COVID-19 pandemic. Topics covered by the papers collected here focus on recent advances in ontology design and patterns, and range from a method to instantiate content patterns, through a proposal on how to document a content pattern, to a number of patterns emerging in ontology modeling in various situations and applications.The book provides an overview of important advances in ontology engineering and ontology design patterns, and will be of interest to all those working in the field.
|
|
| 9. |
- Blomqvist, Eva, et al.
(författare)
-
Preface
- 2021
-
Ingår i: Advances in Pattern-Based Ontology Engineering. - Amsterdam : IOS Press. - 9781643681740 - 9781643681757 ; , s. i-viii
-
Bokkapitel (refereegranskat)
|
|
| 10. |
- Dima, Danai, et al.
(författare)
-
Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Tidskriftsartikel (refereegranskat)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
|
|
