| 1. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :11
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Journal article (peer-reviewed)
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| 4. |
- Bivik, Caroline, et al.
(author)
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Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells
- 2015
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In: Genetics. - : Genetics Society of America. - 0016-6731 .- 1943-2631. ; 200:4, s. 1229-1244
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Journal article (peer-reviewed)abstract
- The expression of neuropeptides is often extremely restricted in the nervous system, making them powerful markers for addressing cell specification . In the developing Drosophila ventral nerve cord, only six cells, the Ap4 neurons, of some 10,000 neurons, express the neuropeptide FMRFamide (FMRFa). Each Ap4/FMRFa neuron is the last-born cell generated by an identifiable and well-studied progenitor cell, neuroblast 5-6 (NB5-6T). The restricted expression of FMRFa and the wealth of information regarding its gene regulation and Ap4 neuron specification makes FMRFa a valuable readout for addressing many aspects of neural development, i.e., spatial and temporal patterning cues, cell cycle control, cell specification, axon transport, and retrograde signaling. To this end, we have conducted a forward genetic screen utilizing an Ap4-specific FMRFa-eGFP transgenic reporter as our readout. A total of 9781 EMS-mutated chromosomes were screened for perturbations in FMRFa-eGFP expression, and 611 mutants were identified. Seventy-nine of the strongest mutants were mapped down to the affected gene by deficiency mapping or whole-genome sequencing. We isolated novel alleles for previously known FMRFa regulators, confirming the validity of the screen. In addition, we identified novel essential genes, including several with previously undefined functions in neural development. Our identification of genes affecting most major steps required for successful terminal differentiation of Ap4 neurons provides a comprehensive view of the genetic flow controlling the generation of highly unique neuronal cell types in the developing nervous system.
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| 5. |
- Hawlader, Mohammad D H, et al.
(author)
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Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children.
- 2014
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In: Tropical Medicine and Health. - : Japanese Society of Tropical Medicine. - 1348-8945 .- 1349-4147. ; 42:2, s. 77-85
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Journal article (peer-reviewed)abstract
- Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children. A total of 912 children aged 4.5 years (mean = 54.4, range = 53.5-60.8 months) participated in a cross-sectional study nested into a randomized controlled trial in Bangladesh. Ever-asthma, ever-wheezing and current wheezing were identified using the International Study of Asthma and Allergies in Childhood questionnaire. Current helminth infection was defined by the presence of helminth eggs in stools, measured by routine microscopic examination. Repeated Ascaris infection was defined by the presence of anti-Ascaris IgE ≥ 0.70 UA/ml in serum measured by the CAP-FEIA method. Atopy was defined by specific IgE to house dust mite (anti-DP IgE) ≥ 0.70 UA/ml measured by the CAP-FEIA method and/or positive skin prick test (≥ 5 mm). Anti-Ascaris IgE was significantly associated with ever asthma (odds ratio (OR) = 1.86, 95% CI: 1.14-3.04, highest vs. lowest quartile; P for trend 0.016). Anti-Ascaris IgE was also significantly associated with positive anti-DP IgE (OR = 9.89, 95% CI: 6.52-15.00, highest vs. lowest; P for trend < 0.001) and positive skin prick test (OR = 1.69, 95% CI: 1.01-2.81, highest vs. lowest, P for trend 0.076). These findings suggest that repeated Ascaris infection is a risk factor for asthma and atopy in rural Bangladeshi children. Further analysis is required to examine the mechanism of developing asthma and atopy in relation to helminth infection.
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| 6. |
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| 7. |
- Rodríguez, Juanjo
(author)
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Mercury methylation in boreal aquatic ecosystems under oxic conditions and climate change : a review
- 2023
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In: Frontiers in Marine Science. - : Frontiers Media S.A.. - 2296-7745. ; 10
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Research review (peer-reviewed)abstract
- Methylmercury (MeHg) formation is a concerning environmental issue described in waters and sediments from multiple aquatic ecosystems. The genetic and metabolic bases of mercury (Hg) methylation have been well described in anoxic environments, but a number of factors seem to point towards alternative pathways potentially occurring in pelagic waters under oxic conditions. Boreal aquatic ecosystems are predicted to undergo increasing concentrations of dissolved organic matter (DOM) as a result of higher terrestrial runoff induced by climate change, which may have important implications in the formation of MeHg in the water column. In this review, different Hg methylation mechanisms postulated in the literature are discussed, with particular focus on potential pathways independent of the hgcAB gene pair and occurring under oxic conditions. Potential effects of DOM on Hg methylation and MeHg bioaccumulation are examined in the context of climate in boreal aquatic ecosystems. Furthermore, the implementation of meta-omic technologies and standardized methods into field measurements and incubation experiments is discussed as a valuable tool to determine taxonomic and functional aspects of Hg methylation in oxic waters and under climate change-induced conditions.
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| 10. |
- Francén, Ragnar, 1977
(author)
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Moral Disagreement and Practical Direction
- 2022
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In: Journal of Ethics and Social Philosophy. - : Journal of Ethics and Social Philosophy. - 1559-3061. ; 23:2, s. 273-303
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Journal article (peer-reviewed)abstract
- Whenever A judges that x-ing is morally wrong and B judges that x-ing is not morally wrong, we think that they disagree. The two standard types of accounts of such moral disagreements both presuppose that the class of moral wrong-judgments is uniform, though in different ways. According to the belief account, the disagreement is doxastic: A and B have beliefs with conflicting cognitive contents. This presupposes “belief-uniformity”: that the content of moral concepts is invariant in such a way that, whenever A believes that x-ing is morally wrong and B believes that x-ing is not morally wrong, their beliefs have mutually inconsistent contents. According to the attitude account, moral disagreements are non-doxastic: A and B have clashing practical attitudes. This presupposes “attitude-uniformity”: that moral judgments are always accompanied by, or consist of, desire-like attitudes. Consequently, neither account is available if both uniformity-claims are rejected – as e.g., various forms of content-relativism do. This paper presents a new non-doxastic account of deontic moral disagreement, consistent with the rejection of both uniformity-claims. I argue first, that even if deontic moral judgments are not desires, and are not always accompanied by desires, they have practical direction in the same sense as desires: they are attitudes that one can act in accordance or discordance with. Second: deontic moral disagreement can be understood as clashes in practical direction: roughly, A and B morally disagree if, and only if, some way of acting is in accordance with A’s judgment but in discordance with B’s.
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