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1.	Maldonado, Mario, et al. (author) Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes 2003 In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 88:11, s. 5090-5098 Journal article (peer-reviewed)abstract Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of diabetes, lower body mass index, less glycemic improvement, and persistent insulin requirement. HLA class II genotyping showed that the A-beta- group differed from the A+beta- group in having lower frequencies of two alleles strongly associated with
2.	Redondo, Maria J, et al. (author) Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes. 2014 In: BMJ open diabetes research & care. - : BMJ. - 2052-4897. ; 2:1, s. 000008-000008 Journal article (peer-reviewed)abstract The transcription factor 7-like 2 (TCF7L2) gene has the strongest genetic association with type 2 diabetes. TCF7L2 also associates with latent autoimmune diabetes in adults, which often presents with a single islet autoantibody, but not with classical type 1 diabetes.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Hampe, Christiane S. (2); Balasubramanyam, Ash ... (2); Iyer, Dinakar (2); Lernmark, Åke (1); Gaur, Lakshmi K (1); Vaziri Sani, Fariba (1); show more...; Redondo, Maria J. (1); Grant, Struan F A (1); Maldonado, Mario (1); D'Amico, Susana (1); Hammerle, Lisa P (1); Bolgiano, Douglas (1); Rodriguez, Lucille (1); Rajan, Arun (1); Muniz, Jesse (1); Rodriguez, Luisa M (1); Haymond, Morey W (1); Metzker, Michael L (1); show less...

University: Lund University (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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