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| 2. |
- Kanatsuna, N, et al.
(author)
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Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes
- 2015
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In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 82:4, s. 361-369
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Journal article (peer-reviewed)abstract
- The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim of this study was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ or both, in patients and controls with newly diagnosed type 1 diabetes. Patients (n = 676), 0-18 years of age, diagnosed with type 1 diabetes in 1996-2005 and controls (n = 363) were analysed for specific INS-IGF2A after displacement with both cold insulin and INS-IGF2 to correct for non-specific binding and identify double reactive sera. GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, ZnT8QA and HLA-DQ genotypes were also determined. The median level of specific INS-IGF2A was higher in patients than in controls (P < 0.001). Irrespective of age at diagnosis, 19% (126/676) of the patients had INS-IGF2A when the cut-off was the 95th percentile of the controls (P < 0.001). The risk of INS-IGF2A was increased among HLA-DQ2/8 (OR = 1.509; 95th CI 1.011, 2.252; P = 0.045) but not in 2/2, 2/X, 8/8, 8/X or X/X (X is neither 2 nor 8) patients. The association with HLA-DQ2/8 suggests that this autoantigen may be presented on HLA-DQ trans-heterodimers, rather than cis-heterodimers. Autoantibodies reactive with both insulin and INS-IGF2A at diagnosis support the notion that INS-IGF2 autoimmunity contributes to type 1 diabetes.
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| 3. |
- Kitzing, Peter, et al.
(author)
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Communication aids for people with aphasia
- 2005
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In: Logopedics Phoniatrics Vocology. - : Informa UK Limited. - 1401-5439 .- 1651-2022. ; 30:1, s. 41-46:30, s. 41-46
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Journal article (peer-reviewed)
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| 4. |
- Lundgren, Markus, et al.
(author)
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Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
- 2014
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X. ; 15:7, s. 494-501
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Journal article (peer-reviewed)abstract
- Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
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| 5. |
- Rasmusson, Elisabeth, et al.
(author)
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Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
- 2013
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In: Radiation Oncology. - 1748-717X. ; 8
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Journal article (peer-reviewed)abstract
- Background: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. Methods: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skane University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2-4.1). Results: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three patients required treatment with compression stockings. Conclusion: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection.
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| 6. |
- Zackrisson, Mats, et al.
(author)
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Life Cycle Assessment and Life Cycle Cost of Waste Management : Plastic Cable Waste
- 2014
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In: Advances in Chemical Engineering and Science. - : Scientific Research Publishing, Inc.. - 2160-0392 .- 2160-0406. ; 4:2
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Journal article (peer-reviewed)abstract
- The main driver for recycling cable wastes is the high value of the conducting metal, while the plastic with its lower value is often neglected. New improved cable plastic recycling routes can provide both economic and environmental incentive to cable producers for moving up the “cable plastic waste ladder”. Cradle-to-gate life cycle assessment, LCA, of the waste management of the cable scrap is suggested and explained as a method to analyze the pros and cons of different cable scrap recycling options at hand. Economic and environmental data about different recycling processes and other relevant processes and materials are given. Cable producers can use this data and method to assess the way they deal with the cable plastic waste today and compare it with available alternatives and thus illuminate the improvement potential of recycling cable plastic waste both in an environmental and in an economic sense. The methodology applied consists of: cradle-to-gate LCA for waste material to a recycled material (recyclate); quantifying the climate impact for each step on the waste ladder for the specific waste material; the use of economic and climate impact data in parallel; climate impact presented as a span to portray the insecurities related to which material the waste will replace; and possibilities for do-it-yourself calculations. Potentially, the methodology can be useful also for other waste materials in the future.
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| 7. |
- Zackrisson, Mats, et al.
(author)
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Mall för miljöutredning - ett verktyg för att identifiera företagets miljöpåverkan
- 2014
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Book (other academic/artistic)abstract
- Mall för miljöutredning hjälper dig att samla in och redovisa kvantitativa data om material- och energiflödet genom det egna företaget. Med hjälp av dessa data skapas en bild som beskriver miljöpåverkan av företagets verksamhet och produkter i ett livscykelperspektiv.Till skriften hör bland annat:• en Wordmall för miljöutredningen, där man fyller i tabeller och justerar texten• ett inventerings- och beräkningsverktyg i Excel, som räknar ut miljöpåverkan av företagets transporter, material, utsläpp och energi• en översikt av miljölagarna för inventering av lagkrav• instruktioner och blanketter för Miljö-FMEA; ett sätt att identifiera och värdera miljöpåverkan.
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| 9. |
- Aksnes, A, et al.
(author)
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Size-fractionated fish hydrolysate as feed ingredient for rainbow trout (Oncorhynchus mykiss) fed high plant protein diets. I: Growth, growth regulation and feed utilization
- 2006
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In: Aquaculture. - : Elsevier BV. - 0044-8486. ; 261:1, s. 305-317
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Journal article (peer-reviewed)abstract
- Six experimental diets were fed to rainbow trout to examine the effect of fish hydrolysate and ultra filtered fish hydrolysate on growth performance, feed utilization and growth regulation using diets low in dietary fish meal inclusion. One diet contained a high level of plant protein sources (90.6% of total dietary protein) and a low level of fish meal (9.4% of dietary protein). Two diets contained different levels of hydrolysate in exchange for the plant protein sources, reducing the plant protein level to 73.9% and 57.2%, respectively. Two further diets were identical in composition except that the hydrolysate was ultra filtered to remove low molecular weight compounds. A moderate level of fish meal was used in the sixth diet which had a dietary plant protein level of 57.0%. All diets were made equal in protein, lipid, energy and lysine. The feeding trial lasted for 90 days and for the fastest growing group, fed moderate level of fish meal, the fish increased in weight from 149 g at start to a final weight of 443 g. All groups showed significant differences in growth and feed utilizations. Specific growth rates were; 0.30% day− 1 for the plant protein diet, 0.98% day− 1 for the high hydrolysate diet, 0.72% day− 1 for the group containing the high level of ultra filtered hydrolysate, and 1.21% day− 1 for the moderate fish meal diet. Feed efficiencies (g fish weight gain per g feed intake) were found to be 0.57 for plant protein diet, 0.97 for high level of hydrolysate, 0.83 for ultra filtered hydrolysate and 1.03 for the moderate fish meal diet. Half dietary inclusions of hydrolysate and ultra filtered hydrolysate revealed values between the plant protein diets and high levels of these ingredients, respectively. Feed consumption in percentage of average fish weight per day, correlated with the feed efficiency for all groups. PER, PPV and BV correlated with the differences in growth. Protein digestibilities were equal for all groups, while the moderate fish meal diet showed higher lipid and energy digestibilities than the plant protein diets. Although some of the differences may be due to growth inhibitors in plant resources other explanations may be relevant. Plasma growth hormone (GH) levels were significantly higher in fish fed the plant protein diet than fish fed the fish meal or high hydrolysate diet, which is most likely a result of their poor feeding status. Plasma IGF-I levels were not affected by diet. Comparisons of groups with similar inclusion of plant ingredients, and thus equal level of growth inhibitors, show that in removing small molecular weight compounds from fish hydrolysate, the growth and feed efficiency were significantly reduced. Some of these small compounds in fish hydrolysate thus seem to be essential for biological performance. Further, as fish meal revealed the best performance, fish muscle protein is not the only nutrient that makes fish meal an essential ingredient in aqua feed for carnivorous fish. This information is important in the work to find replacement of fish meal in a sustainable growing global aquaculture industry.
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| 10. |
- Anderbrant, Olle, et al.
(author)
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Effects of pheromone trap type, position and colour on the catch of the pine sawfly Neodiprion sertifer (Geoff.) (Hym., Diprionidae)
- 1989
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In: Journal of Applied Entomology. - : Wiley. - 0931-2048 .- 1439-0418. ; 107:1-5, s. 365-369
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Journal article (peer-reviewed)abstract
- Two novel easy‐to‐make pheromone traps, a cross‐barrier sticky trap and an open horizontal sticky trap, are described. Both types caught about the same number of male pine sawflies, Neodiprion sertifer, when baited with the synthetic pheromone (2S, 3S, 7S)‐3,7‐dimethylpentadec‐2‐yl acetate. The catch on unbaited cross‐barrier traps was about 17% compared with baited traps, whereas unbaited horizontal traps caught almost no sawflies. There was no difference in catch between horizontal traps positioned close to the stem and at the end of a branch in young Scots pines, but traps on the ground caught less than one tenth of the number caught in traps 1.5 m above ground. The catch in unbaited cross‐barrier traps was dependent on colour, with white being the most attractive. Zur Auswirkung des Pheromonfallentyps, des Aufstellungsorts und der Farbe auf die Fangzahl von Neodiprion sertifer (Geoff.) (Hym., Diprionidae) Es werden zwei neue, einfach herzustellende Pheromonfallentypen, eine Kreuz‐Leimfalle und eine offene, horizontale Leimfalle beschrieben. Mit beiden Fallentypen wurden ungefähr gleich viele männliche Neodiprion sertifer gefangen, wenn die Fallen mit dem synthetischen Pheromon (2S, 3S, 7S)‐3,7‐dimethylpentadec‐2yl‐acetat bestückt waren. Mit den Kreuz‐Leimfallen ohne Pheromon wurden ca. 17 % verglichen mit der Anzahl auf den entsprechenden mit Pheromon bestückten Fallen gefangen. Dagegen wurden mit der Horizontalfalle ohne Pheromon fast keine Blattwespen gefangen. Horizontalfallen, die nahe am Stamm oder am Astende junger Kiefern aufgehängt wurden, unterschieden sich hinsichtlich der Fangleistung nicht. Wurden jedoch die Fallen am Boden aufgestellt, so betrug das Fangergebnis nur noch ca. 1/10 der Fallen, die in 1,5 m Höhe angebracht waren. Die Fangleistung der Fallen ohne Pheromon war abhängig von der Farbe: weiß war die attraktivste Farbe. 1989 Blackwell Verlag GmbH
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