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| 2. |
- Alaridah, Nader, et al.
(author)
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Transmission dynamics study of tuberculosis isolates with whole genome sequencing in southern Sweden
- 2019
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9
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Journal article (peer-reviewed)abstract
- Epidemiological contact tracing complemented with genotyping of clinical Mycobacterium tuberculosis isolates is important for understanding disease transmission. In Sweden, tuberculosis (TB) is mostly reported in migrant and homeless where epidemiologic contact tracing could pose a problem. This study compared epidemiologic linking with genotyping in a low burden country. Mycobacterium tuberculosis isolates (n = 93) collected at Scania University Hospital in Southern Sweden were analysed with the standard genotyping method mycobacterial interspersed repetitive units-variable number tandem repeats (MIRU-VNTR) and the results were compared with whole genome sequencing (WGS). Using a maximum of twelve single nucleotide polymorphisms (SNPs) as the upper threshold of genomic relatedness noted among hosts, we identified 18 clusters with WGS comprising 52 patients with overall pairwise genetic maximum distances ranging from zero to nine SNPs. MIRU-VNTR and WGS clustered the same isolates, although the distribution differed depending on MIRU-VNTR limitations. Both genotyping techniques identified clusters where epidemiologic linking was insufficient, although WGS had higher correlation with epidemiologic data. To summarize, WGS provided better resolution of transmission than MIRU-VNTR in a setting with low TB incidence. WGS predicted epidemiologic links better which could consolidate and correct the epidemiologically linked cases, avoiding thus false clustering.
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| 4. |
- Bergh, Jonas, et al.
(author)
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FACT : An Open-Label Randomized Phase III Study of Fulvestrant and Anastrozole in Combination Compared With Anastrozole Alone as First-Line Therapy for Patients With Receptor-Positive Postmenopausal Breast Cancer
- 2012
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In: Journal of Clinical Oncology. - Alexandria, VA : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:16, s. 1919-1925
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Journal article (peer-reviewed)abstract
- Purpose: To compare the effect of therapy with anastrozole versus a combination of fulvestrant and anastrozole in women in first relapse of endocrine-responsive breast cancer. Patients and Methods: Postmenopausal women, or premenopausal women receiving a gonadotropin-releasing hormone agonist, with estrogen receptor– and/or progesterone receptor–positive disease at first relapse after primary treatment of localized disease were open-label randomly assigned to a fulvestrant loading dose (LD) regimen followed by monthly injection plus 1 mg of anastrozole daily or to 1 mg of anastrozole daily alone. The primary end point was time to progression (TTP). Results: In all, 514 women were randomly assigned to fulvestrant plus anastrozole (experimental arm; n = 258) or anastrozole (standard arm; n = 256). Approximately two thirds had received adjuvant antiestrogens, but only eight individuals had received an aromatase inhibitor. Median TTP was 10.8 and 10.2 months in the experimental versus standard arm, respectively (hazard ratio [HR] = 0.99; 95% CI, 0.81 to 1.20; P = .91); median overall survival was 37.8 and 38.2 months, respectively (HR = 1.0; 95% CI, 0.76 to 1.32; P = 1.00). Incidences of prespecified adverse events (AEs) were similar. Hot flashes were more common in the experimental arm: 63 patients (24.6%) versus 35 patients (13.8%) in the standard arm (P = .0023). Death owing to AEs was reported in 11 (4.3%) and five patients (2.0%) in the experimental versus standard arm, respectively. Conclusion: Fulvestrant (250 mg + LD regimen) in combination with anastrozole offered no clinical efficacy advantage over anastrozole monotherapy in this population of individuals with a relatively high proportion of previous adjuvant antiestrogen exposure.
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| 6. |
- Bergöö, Kerstin, et al.
(author)
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Glädjen i att förstå : språk- och textarbete med barn
- 2012
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Book (other academic/artistic)abstract
- Boken beskriver en aspekt som ofta får alltför lite fokus i arbetet med yngre barn, nämligen ett demokratiskt och kritiskt språkarbete kring sociala rättvisefrågor - s.k. critical literacy. Kärnan i ett sådant arbete är att barnen undersöker texter av olika slag som omger dem. Texterna undersöks med fokus på makt, genus, etnicitet och rättvisa: Vem är det som talar i texten? Vad säger texten oss? Varför? Skulle det kunna vara på något annat sätt?
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| 7. |
- Bergöö, Kerstin, 1942-, et al.
(author)
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Skrivutveckling och undervisning
- 1997
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Book (other academic/artistic)abstract
- Vad utmärker en bra elevtext? Hur påverkas elevernas skrivutveckling av den undervisning de får, och vad menar vi egentligen när vi säger att barns skrivande "utvecklas"? Dessa och andra frågor diskuteras ingående i den här boken där läsaren får följa tre låg- och mellanstadieelevers skrivande över lång tid. Elevernas texter diskuteras och analyseras ur olika perspektiv samt med utgångspunkt i modern teoribildning. Särskild vikt har lagts vid att granska de olika texterna ur ett undervisningsperspektiv. Författarna försöker synliggöra den undervisningskontext i vilken texterna producerats, eftersom förklaringen till en texts kvalitéer och brister ofta står att finna i den undervisningssituation som texten tillkommit i. Syftet med boken är att underlätta för lärare och lärarstuderande i deras strävan att förstå och utveckla sina kunskaper om skrivande, skrivpedagogik och textanalys.Boken är avsedd för grundutbildning och fortbildning av lärare.
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| 8. |
- Bergöö, Kerstin, et al.
(author)
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Skrivutveckling och undervisning
- 1997
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Book (other academic/artistic)abstract
- Vad utmärker en bra elevtext? Hur påverkas elevernas skrivutveckling av den undervisning de får, och vad menar vi egentligen när vi säger att barns skrivande "utvecklas"? Dessa och andra frågor diskuteras ingående i den här boken där läsaren får följa tre låg- och mellanstadieelevers skrivande över lång tid. Elevernas texter diskuteras och analyseras ur olika perspektiv samt med utgångspunkt i modern teoribildning. Särskild vikt har lagts vid att granska de olika texterna ur ett undervisningsperspektiv. Författarna försöker synliggöra den undervisningskontext i vilken texterna producerats, eftersom förklaringen till en texts kvalitéer och brister ofta står att finna i den undervisningssituation som texten tillkommit i. Syftet med boken är att underlätta för lärare och lärarstuderande i deras strävan att förstå och utveckla sina kunskaper om skrivande, skrivpedagogik och textanalys. Boken är avsedd för grundutbildning och fortbildning av lärare.
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| 9. |
- Bogren, Anna, 1963, et al.
(author)
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Long-term effect of the combined use of powered toothbrush and triclosan dentifrice in periodontal maintenance patients.
- 2008
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In: Journal of clinical periodontology. - 1600-051X. ; 35:2, s. 157-64
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Journal article (peer-reviewed)abstract
- AIM: To test the hypothesis of a superior clinical and microbiological effect of the combined use of powered toothbrush+triclosan-containing dentifrice compared with manual toothbrush+regular fluoride-containing dentifrice in periodontal maintenance patients. MATERIAL AND METHODS: A total of 128 periodontitis subjects involved in recall programmes were randomized to use either powered toothbrush with triclosan-dentifrice (test) or manual toothbrush and standard dentifrice (control). Supportive periodontal treatment was provided at baseline and every 6 months. Plaque, bleeding on probing (BoP), probing pocket depth (PPD) and relative attachment level (RAL) were scored at baseline, 1, 2 and 3 years. Subgingival plaque samples were taken and analysed for their content of 40 bacterial species at each examination interval. All analyses were performed by "intention-to-treat" protocol. RESULTS: Both groups showed significant reduction in BoP, PPD and in mean total counts of the 40 bacterial species between baseline and 3 years, while plaque score and RAL remained almost unchanged. No significant differences between the two prevention programmes were found for any of the clinical outcome variables or in mean counts of the various bacterial species. CONCLUSIONS: The study failed to demonstrate superior clinical and microbiological effects of powered toothbrush+triclosan dentifrice compared with manual toothbrush+standard fluoride-dentifrice in periodontitis-susceptible patients on regular maintenance therapy.
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| 10. |
- Breidegard, Björn, et al.
(author)
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Disclosing the secrets of braille reading: Computer-aided registration and interactive analysis
- 2006
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In: Visual Impairment Research. - 1388-235X. ; 8:3, s. 49-59
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Journal article (peer-reviewed)abstract
- The pilot project reported here utilized the first technology ever developed for the computerized on-line registration and analysis of finger movements during Braille reading. Five congenitally blind subjects performed tactile reading of pedagogically carefully selected texts. Two specialists in visual impairments analyzed the computer-registered reading activities using specially designed interaction software. The subjects themselves were interviewed and contributed to discussions about their own individual reading styles. The analyses of this first handful of subjects reveal a number of important strategies and preferences with regard to on-line tactile reading. Further, the results challenge several assumptions and practices in Braille teaching. This pilot project lays the foundation for more comprehensive large-scale studies - both cross-sectional and longitudinal ones - studies long wanted in the domain of tactile reading.
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