| 1. |
- Wendt, Fabian, et al.
(author)
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Ocean energy systemswave energy modelling task: Modelling, verification and validation ofwave energy converters
- 2019
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In: Journal of Marine Science and Engineering. - : MDPI AG. - 2077-1312. ; 7:11
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Journal article (peer-reviewed)abstract
- The International Energy Agency Technology Collaboration Programme for Ocean Energy Systems (OES) initiated the OES Wave Energy Conversion Modelling Task, which focused on the verification and validation of numerical models for simulating wave energy converters (WECs). The long-term goal is to assess the accuracy of and establish confidence in the use of numerical models used in design as well as power performance assessment of WECs. To establish this confidence, the authors used different existing computational modelling tools to simulate given tasks to identify uncertainties related to simulation methodologies: (i) linear potential flow methods; (ii) weakly nonlinear Froude-Krylov methods; and (iii) fully nonlinear methods (fully nonlinear potential flow and Navier-Stokes models). This article summarizes the code-to-code task and code-to-experiment task that have been performed so far in this project, with a focus on investigating the impact of different levels of nonlinearities in the numerical models. Two different WECs were studied and simulated. The first was a heaving semi-submerged sphere, where free-decay tests and both regular and irregular wave cases were investigated in a code-to-code comparison. The second case was a heaving float corresponding to a physical model tested in a wave tank. We considered radiation, diffraction, and regular wave cases and compared quantities, such as the WEC motion, power output and hydrodynamic loading.
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| 2. |
- Abend, Sven, et al.
(author)
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Terrestrial very-long-baseline atom interferometry : Workshop summary
- 2024
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In: AVS Quantum Science. - : American Institute of Physics (AIP). - 2639-0213. ; 6:2
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Research review (peer-reviewed)abstract
- This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more kilometer--scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions.
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| 3. |
- Ahlberg, Daniel, et al.
(author)
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Competition in growth and urns
- 2019
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In: Random structures & algorithms (Print). - : Wiley. - 1042-9832 .- 1098-2418. ; 54:2, s. 211-227
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Journal article (peer-reviewed)abstract
- We study survival among two competing types in two settings: a planar growth model related to two-neighbor bootstrap percolation, and a system of urns with graph-based interactions. In the planar growth model, uncolored sites are given a color at rate 0, 1 or infinity, depending on whether they have zero, one, or at least two neighbors of that color. In the urn scheme, each vertex of a graph G has an associated urn containing some number of either blue or red balls ( but not both). At each time step, a ball is chosen uniformly at random from all those currently present in the system, a ball of the same color is added to each neighboring urn, and balls in the same urn but of different colors annihilate on a one-for-one basis. We show that, for every connected graph G and every initial configuration, only one color survives almost surely. As a corollary, we deduce that in the two-type growth model on Z(2), one of the colors only infects a finite number of sites with probability one. We also discuss generalizations to higher dimensions and multi-type processes, and list a number of open problems and conjectures.
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| 4. |
- Blöndal, Viiu, et al.
(author)
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Allergic sensitisation and type-2 inflammation is associated with new-onset and persistent allergic disease
- 2023
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In: Clinical and Translational Allergy. - : Wiley-Blackwell. - 2045-7022. ; 13:4
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Journal article (peer-reviewed)abstract
- Background: Allergic disease is common. The aim of this study was to look at the change in asthma and rhinitis over time and to characterise factors contributing to remission and persistence of disease.Methods: This cohort study included 255 individuals with or without asthma and or rhinitis that participated in a population survey and a follow-up 10 years later. The participants were tested for allergic sensitisation, total IgE, multiplex allergen component analysis and type-2 inflammatory markers: exhaled nitric oxide (FENO), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN).Results: Of the 132 healthy individuals, 112 remained healthy, 16 developed rhinitis, 4 asthma and rhinitis over the 10 years. Out of 82 subjects with rhinitis, 26 went into remission, 53 remained unchanged and 3 developed asthma in addition to rhinitis. None of the 41 participants with asthma and rhinitis went into remission. Subjects with persistent rhinitis and asthma had higher levels of total IgE (odds ratio [OR] 95% confidence interval [CI]: 6.16 [3.05-12.5]) at baseline and after 10 years, and FENO and ECP at baseline (OR per log unit increase, 95% CI 5.21 [1.20-22.7] and 6.32 [1.52-26.4], respectively), compared with those that remained healthy. Subjects with persistent rhinitis were more likely to be sensitised to grass pollen and had higher total IgE levels than those that went into remission. Individuals with persistent asthma were more likely to be sensitised to tree pollen and furry animals than those with only persistent rhinitis (OR 95% CI: 3.50 [1.29-9.49] and 6.73 [2.00-22.6], respectively).Conclusion: IgE sensitisation and total IgE levels are associated with the persistence of rhinitis and asthma. Participants with persistent allergic disease had higher levels of allergen sensitisation and type 2 inflammation markers at baseline than those who remained healthy.
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| 5. |
- Bruhn-Olszewska, Bozena, et al.
(author)
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Loss of Y in leukocytes as a risk factor for critical COVID-19 in men.
- 2022
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In: Genome medicine. - : Springer Science and Business Media LLC. - 1756-994X. ; 14:1
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Journal article (peer-reviewed)abstract
- The COVID-19 pandemic, which has a prominent social and economic impact worldwide, shows a largely unexplained male bias for the severity and mortality of the disease. Loss of chromosome Y (LOY) is a risk factor candidate in COVID-19 due to its prior association with many chronic age-related diseases, and its impact on immune gene transcription.Publicly available scRNA-seq data of PBMC samples derived from male patients critically ill with COVID-19 were reanalyzed, and LOY status was added to the annotated cells. We further studied LOY in whole blood for 211 COVID-19 patients treated at intensive care units (ICU) from the first and second waves of the pandemic. Of these, 139 patients were subject to cell sorting for LOY analysis in granulocytes, low-density neutrophils (LDNs), monocytes, and PBMCs.Reanalysis of available scRNA-seq data revealed LDNs and monocytes as the cell types most affected by LOY. Subsequently, DNA analysis indicated that 46%, 32%, and 29% of critically ill patients showed LOY above 5% cut-off in LDNs, granulocytes, and monocytes, respectively. Hence, the myeloid lineage that is crucial for the development of severe COVID-19 phenotype is affected by LOY. Moreover, LOY correlated with increasing WHO score (median difference 1.59%, 95% HDI 0.46% to 2.71%, p=0.025), death during ICU treatment (median difference 1.46%, 95% HDI 0.47% to 2.43%, p=0.0036), and history of vessel disease (median difference 2.16%, 95% HDI 0.74% to 3.7%, p=0.004), among other variables. In 16 recovered patients, sampled during ICU stay and 93-143 days later, LOY decreased significantly in whole blood and PBMCs. Furthermore, the number of LDNs at the recovery stage decreased dramatically (median difference 76.4 per 10,000 cell sorting events, 95% HDI 55.5 to 104, p=6e-11).We present a link between LOY and an acute, life-threatening infectious disease. Furthermore, this study highlights LOY as the most prominent clonal mutation affecting the myeloid cell lineage during emergency myelopoiesis. The correlation between LOY level and COVID-19 severity might suggest that this mutation affects the functions of monocytes and neutrophils, which could have consequences for male innate immunity.
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| 6. |
- Capdevila, Jaume, et al.
(author)
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Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms
- 2019
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In: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 108:1, s. 18-25
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Journal article (peer-reviewed)abstract
- Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.
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| 7. |
- Diaconis, Persi, et al.
(author)
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Note on a partition limit theorem for rank and crank
- 2013
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In: Bulletin of the London Mathematical Society. - : Wiley. - 0024-6093 .- 1469-2120. ; 45:3, s. 551-553
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Journal article (peer-reviewed)abstract
- If lambda is a partition of n, then the rank rk(lambda) is the size of the largest part minus the number of parts. Under the uniform distribution on partitions, in K. Bringmann, K. Mahlburg, and R. C. Rhoades (Bull. Lond. Math. Soc., 43 (2011) 661-672), it is shown that has a limiting distribution. We identify the limit as the difference between two independent extreme value distributions and as the distribution of beta(T), where beta(t) is standard Brownian motion and T is the first time that an independendent 3-dimensional Brownian motion hits the unit sphere. The same limit holds for the crank.
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| 8. |
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| 9. |
- Ekbom, Emil, et al.
(author)
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Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge
- 2021
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In: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 182
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Journal article (peer-reviewed)abstract
- There is limited knowledge about the long-term effects on pulmonary function of COVID-19 in patients that required intensive care treatment. Spirometry and diffusing capacity for carbon monoxide (DLCO) were measured in 60 subjects at 3-6 months post discharge. Impaired lung function was found in 52% of the subjects, with reduced DLCO as the main finding. The risk increased with age above 60 years, need for mechanical ventilation and longer ICU stay as well as lower levels of C-reactive protein at admission. This suggests the need of follow-up with pulmonary function testing in intensive-care treated patients.
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| 10. |
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