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Träfflista för sökning "WFRF:(Jensen Henry) "

Search: WFRF:(Jensen Henry)

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1.
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2.
  • Aad, G., et al. (author)
  • 2011
  • Journal article (peer-reviewed)
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3.
  • Aad, G., et al. (author)
  • 2012
  • Journal article (peer-reviewed)
  •  
4.
  • Aad, G., et al. (author)
  • 2012
  • Journal article (peer-reviewed)
  •  
5.
  • Aad, G., et al. (author)
  • 2012
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :7
  • Journal article (peer-reviewed)
  •  
6.
  • Aad, G., et al. (author)
  • 2012
  • In: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 108:26
  • Journal article (peer-reviewed)
  •  
7.
  • Aad, G., et al. (author)
  • 2012
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
  • Journal article (peer-reviewed)
  •  
8.
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9.
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10.
  • Kanoni, Stavroula, et al. (author)
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
  • 2022
  • In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
  • Journal article (peer-reviewed)abstract
    • Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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  • Result 1-10 of 176
Type of publication
journal article (51)
conference paper (3)
research review (1)
Type of content
peer-reviewed (173)
Author/Editor
Abi, B. (145)
Abramowicz, H. (145)
Abreu, H. (145)
Adelman, J. (145)
Adomeit, S. (145)
Adye, T. (145)
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Akimoto, G. (145)
Akimov, A. V. (145)
Aleksa, M. (145)
Alexandre, G. (145)
Alhroob, M. (145)
Allport, P. P. (145)
Amelung, C. (145)
Anastopoulos, C. (145)
Angerami, A. (145)
Annovi, A. (145)
Antonaki, A. (145)
Antonelli, M. (145)
Arabidze, G. (145)
Aracena, I. (145)
Arai, Y. (145)
Arguin, J-F. (145)
Arnaez, O. (145)
Artamonov, A. (145)
Asai, S. (145)
Asquith, L. (145)
Assamagan, K. (145)
Azuma, Y. (145)
Bachacou, H. (145)
Bachas, K. (145)
Backes, M. (145)
Bain, T. (145)
Baker, O. K. (145)
Banas, E. (145)
Barak, L. (145)
Barbero, M. (145)
Barillari, T. (145)
Barisonzi, M. (145)
Barklow, T. (145)
Bartoldus, R. (145)
Battistin, M. (145)
Bawa, H. S. (145)
Beau, T. (145)
Beck, H. P. (145)
Beckingham, M. (145)
Bella, G. (145)
Belotskiy, K. (145)
Beltramello, O. (145)
Benary, O. (145)
Benekos, N. (145)
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University
Lund University (22)
Uppsala University (21)
Royal Institute of Technology (15)
Stockholm University (14)
Karolinska Institutet (9)
Linköping University (8)
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University of Gothenburg (6)
Mid Sweden University (4)
Högskolan Dalarna (3)
Umeå University (2)
Örebro University (2)
Chalmers University of Technology (2)
RISE (1)
Swedish University of Agricultural Sciences (1)
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Language
English (176)
Research subject (UKÄ/SCB)
Natural sciences (21)
Medical and Health Sciences (13)
Agricultural Sciences (1)
Social Sciences (1)

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