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1.	Boehme, JD, et al. (author) Bacterial-strain dependency in secondary pneumococcal pneumonia in the post-influenza lung - a role for alveolar type II epithelial cells? 2019 In: EUROPEAN JOURNAL OF IMMUNOLOGY. - 0014-2980. ; 49, s. 102-103 Conference paper (other academic/artistic)
2.	Joshua, F, et al. (author) Phenotype and function of T regulatory cells and their role in HIV infection 2008 In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - 0300-9475. ; 68:2, s. 254-254 Conference paper (other academic/artistic)
3.	Law, Andrew M. K., et al. (author) ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo 2022 In: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 9:21 Journal article (peer-reviewed)abstract To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate-based tissue engineering (ALTEN), a biomimetic tissue platform that allows ex vivo analysis of explanted tissue biopsies. This method preserves the original characteristics of the source tissue's cellular milieu, allowing multiple and diverse cell types to be maintained over an extended period of time. As a result, ALTEN enables rapid and faithful characterization of perturbations across specific cell types within a tissue. Importantly, using single-cell genomics, this approach provides integrated cellular responses at the resolution of individual cells. ALTEN is a powerful tool for the analysis of cellular responses upon exposure to cytotoxic agents and immunomodulators. Additionally, ALTEN's scalability using automated microfluidic devices for tissue encapsulation and subsequent transport, to enable centralized high-throughput analysis of samples gathered by large-scale multicenter studies, is shown.

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Type of publication: conference paper (2); journal article (1)

Type of content: other academic/artistic (2); peer-reviewed (1)

Author/Editor: Jeron, A (2); Andersson, J (1); Michaelsson, J (1); Henriques-Normark, B (1); Brighenti, S (1); Boehme, JD (1); show more...; Sharma-Chawla, N (1); Sender, V (1); Stegemann-Koniszewsk ... (1); Bruder, D (1); Skhinas, Joanna N. (1); Cox, Thomas R. (1); Tavakoli, Javad (1); Joshua, F (1); Law, Andrew M. K. (1); Chen, Jiamin (1); Colino‐Sanguino, Yol ... (1); de la Fuente, Laura ... (1); Fang, Guocheng (1); Grimes, Susan M. (1); Lu, Hongxu (1); Huang, Robert J. (1); Boyle, Sarah T. (1); Venhuizen, Jeron (1); Castillo, Lesley (1); Millar, Ewan K. A. (1); Beretov, Julia (1); Rossello, Fernando J ... (1); Tipper, Joanne L. (1); Ormandy, Christopher ... (1); Samuel, Michael S. (1); Martelotto, Luciano (1); Jin, Dayong (1); Valdes‐Mora, Fatima (1); Ji, Hanlee P. (1); Gallego‐Ortega, Davi ... (1); show less...

University: Karolinska Institutet (2); Luleå University of Technology (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (1)

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