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- Munn-Chernoff, M. A., et al.
(author)
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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
- 2021
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In: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 26:1
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Journal article (peer-reviewed)abstract
- Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
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| 3. |
- Abadzhiev, Andrey, 1980-, et al.
(author)
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Business model innovation for reducing uncertainty in sustainability transitions : A case study of the wood construction industry
- 2024
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In: Creativity and Innovation Management. - : John Wiley & Sons. - 0963-1690 .- 1467-8691.
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Journal article (peer-reviewed)abstract
- Sustainability transitions are a significant challenge that requires established industries to adopt innovative ways of doing business. Research suggests that while this is possible through business model innovation (BMI), risk avoidance by regime actors and high levels of future uncertainty act as barriers to successful transitions. Specifically, we lack knowledge about how established companies innovate their business model (BM) to reduce uncertainty related to sustainability transitions. We explore the case of a large forest-based manufacturing company in the construction industry, Stora Enso. We find that, by pursuing transformative BMI and combining multiple value creation logics, a company can reduce different types of uncertainty while shaping its business ecosystem towards more sustainable opportunities. We show that the BM can serve as an organizational tool for collectively exploring new knowledge, reducing uncertainty and driving change in a business ecosystem.
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| 4. |
- Abadzhiev, Andrey, 1980-, et al.
(author)
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Managing the complexity of green innovation
- 2022
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In: European Journal of Innovation Management. - : Emerald Group Publishing Limited. - 1460-1060 .- 1758-7115. ; 25:6, s. 850-866
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Journal article (peer-reviewed)abstract
- Purpose Green innovation can promote both environmental sustainability and economic growth. However, its development and implementation can be complex due to the need to align innovation activities within and across companies. In this study, the authors examined how this complexity can be managed by analyzing how individual companies combine different innovation activities to develop green innovation, and how companies along the value chain align to implement these innovations. Design/methodology/approach The dataset comprises both interviews and a survey of senior executives from the Swedish wood construction industry. These data were first analyzed by using fuzzy set qualitative comparative analysis (fsQCA) to identify innovation activity configurations at the level of the individual company. The interviews were then analyzed to identify alignment mechanisms enabling the implementation of green innovation along the value chain. Findings At the company level, the authors found three innovation activity configurations with varying levels of complexity: (1) systemic innovation by proactive companies, (2) process innovation by reactive companies and (3) inaction by technology-independent companies. On the value chain level, the authors found three alignment mechanisms that facilitate the implementation of green innovation along the value chain. These mechanisms promote cooperation by increasing efficiency, opening up new market opportunities and increasing the level of servitization. Originality/value This paper analyzes the complexity of green innovation and provides novel insights into how complexity is managed at the level of both the individual company and the value chain.
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| 5. |
- Abadzhiev, Andrey, 1980-
(author)
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Wood We Change? : Business Model Innovation Towards Sustainability Transitions: Studying the Wood Construction Industry
- 2021
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Licentiate thesis (other academic/artistic)abstract
- Innovations based on sustainable technologies have been widely considered as a remedy for addressing societal and environmental problems in many industries. However, the large-scale adoption of such innovations goes beyond technology and requires organizing the business in a way that drive industrial transformations across actors and system layers, such as market structures, institutional frames, consumer behavior, and business values. The aim of this dissertation is to understand how industrial firms organize for system change towards sustainability. The study is a compilation of two papers within the same research context: the development of sustainable technology in the construction industry. The overlapping unit of analysis for both papers is business model innovation. Paper I examines how industry firms combine and complement business models with different innovation types to accelerate sustainable technology. Paper II identifies how a change in the business model and value creation logic that occur on a firm level accelerate sustainable technology and shape the socio-technical system. Together, both papers help paint a more complete picture of the business model role in transitions towards sustainability. The theoretical frame of this dissertation spans several domains: business model, innovation management, and sustainability transitions. Building on a multi-disciplinary premise, the study takes into account the organizational and the systemic parts of the change process by linking the company perspective (business models) to the wider governance of sustainability transitions. The findings underline the importance of business models that combine production efficiency with higher customer engagement and more collective value creation for driving larger-scale transitions toward sustainability. Moreover, business models in combination with different innovation types, such as product, process and positioning, act together and complement each other to achieve high sustainability and business outcomes.
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| 6. |
- Bergmann, O., et al.
(author)
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The Age of Olfactory Bulb Neurons in Humans
- 2012
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In: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 74:4, s. 634-639
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Journal article (peer-reviewed)abstract
- Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived C-14 in genomic DNA. We report that C-14 concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.
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| 7. |
- Blokland, G. A. M., et al.
(author)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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In: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
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Journal article (peer-reviewed)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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| 9. |
- Davoudi, Sara, et al.
(author)
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Organizational structure and learning : The case of Swedish public transport authorities
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Other publication (other academic/artistic)abstract
- Purpose – The purpose of this article is to explore how organizational structure and information processes frame the abilities of organizations to reach their objectives. Design/methodology/approach – This paper uses multiple cases to gain a holistic understanding of the role of organizational structure in learning within public organizations. This study comprises 11 semi-structured phone interviews with 11 respondents each representing a Regional public transport authority (RPTA) in Sweden.Findings –This article argues that the organizational structures and personal or impersonal information processing mechanisms in Swedish public transport influence the search for information and subsequent organizational learning influencing the RPTAs’ ability to reach their objectives.Originality/value – Unlike previous studies, this article shows how organizational structures in public organization, such as Swedish public transport, are decided based on political compromises rather the needs to solve coordination problems.
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