| 1. |
|
|
| 2. |
- Jonasson, Anette, et al.
(author)
-
Innate immunity glycoprotein gp-340 variants may modulate human susceptibility to dental caries
- 2007
-
In: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 7, s. 57-
-
Journal article (peer-reviewed)abstract
- Background: Bacterial adhesion is an important determinant of colonization and infection, including dental caries. The salivary scavenger receptor cysteine-rich glycoprotein gp-340, which mediates adhesion of Streptococcus mutans (implicated in caries), harbours three major size variants, designated gp-340 I to III, each specific to an individual saliva. Here we have examined the association of the gp-340 I to III polymorphisms with caries experience and adhesion of S. mutans. Methods: A case-referent study was performed in 12-year-old Swedish children with high (n = 19) or low (n = 19) caries experiences. We measured the gp-340 I to III saliva phenotypes and correlated those with multiple outcome measures for caries experience and saliva adhesion of S. mutans using the partial least squares (PLS) multivariate projection technique. In addition, we used traditional statistics and 2-year caries increment to verify the established PLS associations, and bacterial adhesion to purified gp-340 I to III proteins to support possible mechanisms. Results: All except one subject were typed as gp-340 I to III (10, 23 and 4, respectively). The gp-340 I phenotype correlated positively with caries experience (VIP = 1.37) and saliva adhesion of S. mutans Ingbritt (VIP = 1.47). The gp-340 II and III phenotypes tended to behave in the opposite way. Moreover, the gp-340 I phenotype tended to show an increased 2-year caries increment compared to phenotypes II/III. Purified gp-340 I protein mediated markedly higher adhesion of S. mutans strains Ingbritt and NG8 and Lactococcus lactis expressing AgI/II adhesins (SpaP or PAc) compared to gp-340 II and III proteins. In addition, the gp-340 I protein appeared over represented in subjects positive for Db, an allelic acidic PRP variant associated with caries, and subjects positive for both gp-340 I and Db tended to experience more caries than those negative for both proteins. Conclusion: Gp-340 I behaves as a caries susceptibility protein.
|
|
| 3. |
- Jonasson, Mikael, 1962-, et al.
(author)
-
Editorial
- 2013
-
In: Scandinavian Journal of Hospitality and Tourism. - Abingdon : Routledge. - 1502-2250 .- 1502-2269. ; 13:2, s. 85-87
-
Journal article (peer-reviewed)
|
|
| 4. |
- Jonasson, Mikael, 1962-, et al.
(author)
-
Performing Guided Tours : Editorial
- 2013
-
In: Scandinavian Journal of Hospitality and Tourism. - Abingdon : Routledge. - 1502-2250 .- 1502-2269. ; 13:2, s. 85-87
-
Journal article (peer-reviewed)
|
|
| 5. |
- Mahmood, Zeid, et al.
(author)
-
The effect of acute exercise on interleukin-6 and hypothalamic-pituitary-adrenal axis responses in patients with coronary artery disease
- 2020
-
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10
-
Journal article (peer-reviewed)abstract
- Vulnerability to stress-induced inflammation has been linked to a dysfunctional hypothalamus–pituitary–adrenal (HPA) axis. In the present study, patients with known or suspected coronary artery disease (CAD) were assessed with respect to inflammatory and HPA axis response to acute physical exercise. An exercise stress test was combined with SPECT myocardial perfusion imaging. Plasma and saliva samples were collected before and 30 min after exercise. Interleukin (IL)-6 and adrenocorticotropic hormone (ACTH) were measured in plasma, while cortisol was measured in both plasma and saliva. In total, 124 patients were included of whom 29% had a prior history of CAD and/or a myocardial perfusion deficit. The levels of exercise intensity and duration were comparable in CAD and non-CAD patients. However, in CAD patients, IL-6 increased after exercise (p = 0.019) while no differences were seen in HPA axis variables. Conversely, patients without CAD exhibited increased levels of ACTH (p = 0.003) and cortisol (p = 0.004 in plasma, p = 0.006 in saliva), but no change in IL-6. We conclude that the IL-6 response to acute physical exercise is exaggerated in CAD patients and may be out of balance due to HPA axis hypoactivity. It remains to be further investigated whether this imbalance is a potential diagnostic and therapeutic target in CAD.
|
|
