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Search: WFRF:(Kaitsuka Taku)

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  • Chen, Jun, et al. (author)
  • Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice
  • 2016
  • In: Neuroscience Letters. - : Elsevier BV. - 0304-3940. ; 629, s. 221-226
  • Journal article (peer-reviewed)abstract
    • Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Chen, Jun (1)
Kaitsuka, Taku (1)
Fujino, Rika (1)
Araki, Kimi (1)
Tomizawa, Kazuhito (1)
Yamamoto, Tetsuro (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2016 (1)

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