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  • Hernandez, Frank J, et al. (author)
  • Aptamers as a model for functional evaluation of LNA and 2′-amino LNA
  • 2009
  • In: Bioorganic & Medicinal Chemistry Letters. - : Pergamon Press. - 0960-894X .- 1464-3405. ; 19:23, s. 6585-6587
  • Journal article (peer-reviewed)abstract
    • The affinity change upon incorporation of LNA and 2′-amino-LNA monomers into an avidin binding DNA aptamer is described. The kinetic profile of selected modified-aptamer was obtained by surface plasmon resonance experiments and compared with the profile of the parent unmodified DNA aptamer. We report significant improvement of avidin binding affinity by the incorporation of single LNA modifications into the aptamer, and successful incorporation of 2′-amino LNA as a novel monomer in aptamers with potential function as carrier unit for additional molecular entities. © 2009 Elsevier Ltd. All rights reserved.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Wengel, Jesper (1)
Hernandez, Frank J (1)
Kalra, Neerja (1)
Vester, Birte (1)
University
Linköping University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2009 (1)

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