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- Pourakbari, R, et al.
(author)
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Early stage evaluation of colon cancer using tungsten disulfide quantum dots and bacteriophage nano-biocomposite as an efficient electrochemical platform
- 2022
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In: CANCER NANOTECHNOLOGY. - : Springer Science and Business Media LLC. - 1868-6958 .- 1868-6966. ; 13:1
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Journal article (other academic/artistic)abstract
- BackgroundRecently, biosensors have become popular analytical tools for small analytes due to their high sensitivity and wide analytical range. In the present work, development of a novel biosensing method based on tungsten disulfide quantum dots (WS2QDs)-Au for rapidly and selectively detecting c-Met protein is introduced. As a proof of concept, M13 bacteriophage-based biosensors were used for the electrochemical detection of c-Met protein as a colon cancer biomarker.MethodThe M13 bacteriophage (virus), as the biorecognition element, was immobilized on glassy carbon electrodes which were modified by WS2QDs-functionalized gold nanoparticles. The stepwise presence of the WS2QDs, gold nanoparticles, and immobilized phage on glassy carbon electrodes were confirmed by scanning electron microscope (SEM) and square wave voltammetry (SWV) technique.ResultsThe designed biosensor was applied to measure the amount of c-Met protein in standard solutions, and consequently the desirable detection limit of 1 pg was obtained. Finally, as a proof of concept, the developed platform was used for the evaluation of c-Met protein in serum samples of colon cancer-suffering patients and the results were compared with the results of the common Elisa kit.ConclusionsAs an interesting part of this study, some concentrations of the c-Met protein in colon cancer serum samples which could not be determined by Elisa, were easily analyzed by the developed bioassay system. The developed bioassay system has great potential to application in biomedical laboratories.Graphical Abstract
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- Amiri, V., et al.
(author)
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Groundwater quality evaluation using Shannon information theory and human health risk assessment in Yazd province, central plateau of Iran
- 2020
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In: Environmental Science and Pollution Research. - : Springer. - 0944-1344 .- 1614-7499.
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Journal article (peer-reviewed)abstract
- This study aims to evaluate the quality of groundwater in the most arid province of Iran, Yazd. It is highly dependent on groundwater resources to meet the domestic, industrial, and agricultural water demand. Position of water samples on the modified Gibbs diagram demonstrates that the interaction with silicates and the increase in direct cation exchange are responsible for the increased salinity of groundwater. Based on entropy theory, the decreasing order of importance of variables in controlling groundwater chemistry is Fe > As > Ba > Hg > NO2 > Pb > K > Cl > Na > Mg > SO4 > NO3 > HCO3 > Ca. The results of entropy weighted water quality index (EWWQI) calculation show that about 34 and 32% of 206 samples in the wet and dry seasons, respectively, are classified as extremely poor quality (ranks 4 and 5). Approximately 60 and 55% of 206 samples in wet and dry seasons, respectively, have excellent, good, and medium quality (ranks 1, 2, and 3). The non-carcinogenic human health risk (NHHR) from intake and dermal contact pathways using deterministic approach show that 36 and 17 samples in both seasons are not suitable for drinking by children. Furthermore, 9 and 2 samples are not suitable for drinking by adults. The results show that children are more vulnerable than adults to these health risks. The non-carcinogenic risks through dermal contact were negligible.
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