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  • Karaghiosoff, M, et al. (author)
  • Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
  • 2003
  • In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 4:5, s. 471-477
  • Journal article (peer-reviewed)abstract
    • Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished. However, Tyk2-null mice showed normal systemic production of nitric oxide and proinflammatory cytokines and the in vivo response to tumor necrosis factor (TNF) was unperturbed. IFN-beta-null but not STAT1-null mice were also resistant to high dose LPS treatment. Together, these data suggest that Tyk2 and IFN-beta are essential effectors in LPS induced lethality.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Müller, M. (1)
Decker, T (1)
Leanderson, Tomas (1)
Bogdan, C. (1)
Levy, D (1)
Kolbe, T. (1)
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Karaghiosoff, M (1)
Steinborn, R (1)
Kovarik, P (1)
Kriegshauser, G (1)
Baccarini, M (1)
Donabauer, B (1)
Reichart, U (1)
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University
Lund University (1)
Language
English (1)
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Medical and Health Sciences (1)
Year
2003 (1)

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