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1.	Bhattacharjee, S, et al. (author) Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury 2017 In: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 3:9, s. e1700735- Journal article (peer-reviewed)abstract We report the discovery of a novel family of prohomeostatic and neuroprotective lipid mediators called elovanoids.
2.	Jun, B, et al. (author) Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity 2017 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 5279- Journal article (peer-reviewed)abstract Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (≥C28) polyunsaturated fatty acids including n-3 (VLC-PUFAs,n-3). While ELOVL4 mutations are linked to vision loss and neuronal dysfunctions, the roles of VLC-PUFAs remain unknown. Here we report a novel class of lipid mediators biosynthesized in human retinal pigment epithelial (RPE) cells that are oxygenated derivatives of VLC-PUFAs,n-3; we termed these mediators elovanoids (ELV). ELVs have structures reminiscent of docosanoids but with different physicochemical properties and alternatively-regulated biosynthetic pathways. The structures, stereochemistry, and bioactivity of ELVs were determined using synthetic materials produced by stereo-controlled chemical synthesis. ELVs enhance expression of pro-survival proteins in cells undergoing uncompensated oxidative stress. Our findings unveil a novel autocrine/paracrine pro-homeostatic RPE cell signaling that aims to sustain photoreceptor cell integrity and reveal potential therapeutic targets for retinal degenerations.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Yang, R. (2); Bazan, NG (2); Petasis, NA (2); Bhattacharjee, S (2); Jun, B (2); Heap, J (2); show more...; Kautzmann, MA (2); Asatryan, A (1); Gordon, WC (1); Mukherjee, PK (1); Khoutorova, L (1); Obenaus, A (1); Belayev, L (1); Menghani, H (1); Marcell, SJ (1); show less...

University: Karolinska Institutet (2)

Language: English (2)

Year: 2017 (2)

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