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Search: WFRF:(Khalfan L)

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1.
  • Karlsson, Anna, 1967, et al. (author)
  • Neutrophil alkaline phosphatase activity increase in bacterial infections is not associated with a general increase in secretory vesicle membrane components.
  • 1995
  • In: Infection and immunity. - 0019-9567. ; 63:3, s. 911-6
  • Journal article (peer-reviewed)abstract
    • The content of alkaline phosphatase (ALP) was determined in neutrophils isolated from patients with acute bacterial infections by a standard enzyme assay. Compared with control cells, patient cells exhibited about a fivefold increase in ALP activity. There was no difference between the ALP Km values of control and patient cells, which indicates that the elevated activity in patient cells was due to the presence of increased amounts of the enzyme. The ALP isozyme in both cell types was determined to be the tissue-unspecific ALP. The fact that much of the ALP activity was measurable only in the presence of detergent suggested that the enzyme was localized in the secretory vesicles, a putative reservoir of plasma membrane components. The amount and subcellular distribution of two other secretory vesicle membrane proteins, i.e., cytochrome b and complement receptor 3, were not altered; hence, we conclude that there was no general increase in amounts of secretory vesicle membrane constituents in the patient cells.
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2.
  • Khalfan, L, et al. (author)
  • Lack of correlation between NADPH-oxidase priming and elevated alkaline phosphatase activity in cord blood neutrophils.
  • 1995
  • In: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - 0905-6157. ; 6:3, s. 161-4
  • Journal article (peer-reviewed)abstract
    • Human neutrophils were isolated from cord blood drawn after Caesarean section deliveries without labour and from peripheral blood from healthy adults. The alkaline phosphatase (ALP) activity in the cell populations was compared with the release of respiratory burst products after activation with the chemoattractant n-formyl-methionyl-leucyl-phenylalanine (fMLP). In contrast to cord blood neutrophils obtained from babies after normal vaginal deliveries, the Caesarean section neutrophils were not metabolically primed. However, like the neutrophils from vaginally delivered babies, the Caesarean section neutrophils showed an increased ALP activity compared to adult control neutrophils. These findings indicate that priming of cord blood neutrophils appears to be induced by labour and can be dissociated from increased ALP activity.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Dahlgren, Claes, 194 ... (2)
Karlsson, Anna, 1967 (2)
Khalfan, L (2)
Björkstén, B (1)
Follin, P. (1)
Stigbrand, T. (1)
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Lundqvist, H (1)
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University
University of Gothenburg (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
1995 (2)

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