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Search: WFRF:(Khodadadi L)

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  • Vasilevskaya, A., et al. (author)
  • Investigating the use of plasma pTau181 in retired contact sports athletes
  • 2022
  • In: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 269, s. 5582-5595
  • Journal article (peer-reviewed)abstract
    • Background: Considering the wide range of outcomes following sport-related concussions, biomarkers are needed to detect underlying pathological changes. The objective was to analyze the use of plasma phosphorylated tau 181 (pTau181) as a non-invasive measure of underlying brain changes in a cohort of retired contact sports athletes at risk of neurodegeneration. Methods: Fifty-four retired contact sport athletes and 27 healthy controls whose blood plasma was analyzed for pTau181 were included. A portion (N = 21) of retired athletes had a 2-years follow-up visit. All participants had completed a neuropsychological battery and MRI imaging. Results: Plasma pTau181 was significantly higher in retired athletes compared to healthy controls (8.94 ± 5.08pg/mL vs. 6.00 ± 2.53pg/mL, respectively; 95% BCa CI 1.38–4.62; p = 0.02); and was significantly associated with fornix fractional anisotropy values only in the athletes group (β = − 0.002; 95% BCa CI − 0.003 to − 0.001; p = 0.002). When the retired athletes cohort was divided into high vs. normal pTau181 groups, the corpus callosum (CC) volume and white-matter integrity was significantly lower in high pTau181 compared to older healthy controls (CC volume: 1.57 ± 0.19 vs. 2.02 ± 0.32, p = 0.002; CC medial diffusivity: 0.96 ± 0.04 × 10–3 mm2/s vs. 0.90 ± 0.03 × 10–3 mm2/s, p = 0.003; CC axial diffusivity: 1.49 ± 0.04 × 10–3 mm2/s vs. 1.41 ± 0.02 × 10–3 mm2/s, p < 0.001, respectively). Conclusions: Although high plasma pTau181 levels were associated with abnormalities in CC and fornix, baseline pTau181 did not predict longitudinal changes in regional brain volumes or white-matter integrity in the athletes. pTau181 may be useful for identifying those with brain abnormalities related to repeated concussion but not for predicting progression.
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