| 1. |
- Radek, Linda, et al.
(author)
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On no man's land : Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents
- 2021
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In: Consciousness and Cognition. - : Elsevier. - 1053-8100 .- 1090-2376. ; 96
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Journal article (peer-reviewed)abstract
- To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
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| 2. |
- Roslin, Tomas, et al.
(author)
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A molecular-based identification resource for the arthropods of Finland
- 2022
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In: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 22:2, s. 803-822
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Journal article (peer-reviewed)abstract
- To associate specimens identified by molecular characters to other biological knowledge, we need reference sequences annotated by Linnaean taxonomy. In this study, we (1) report the creation of a comprehensive reference library of DNA barcodes for the arthropods of an entire country (Finland), (2) publish this library, and (3) deliver a new identification tool for insects and spiders, as based on this resource. The reference library contains mtDNA COI barcodes for 11,275 (43%) of 26,437 arthropod species known from Finland, including 10,811 (45%) of 23,956 insect species. To quantify the improvement in identification accuracy enabled by the current reference library, we ran 1000 Finnish insect and spider species through the Barcode of Life Data system (BOLD) identification engine. Of these, 91% were correctly assigned to a unique species when compared to the new reference library alone, 85% were correctly identified when compared to BOLD with the new material included, and 75% with the new material excluded. To capitalize on this resource, we used the new reference material to train a probabilistic taxonomic assignment tool, FinPROTAX, scoring high success. For the full-length barcode region, the accuracy of taxonomic assignments at the level of classes, orders, families, subfamilies, tribes, genera, and species reached 99.9%, 99.9%, 99.8%, 99.7%, 99.4%, 96.8%, and 88.5%, respectively. The FinBOL arthropod reference library and FinPROTAX are available through the Finnish Biodiversity Information Facility (www.laji.fi) at https://laji.fi/en/theme/protax. Overall, the FinBOL investment represents a massive capacity-transfer from the taxonomic community of Finland to all sectors of society.
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| 3. |
- Guang, Liang, et al.
(author)
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Autonomous DVFS on Supply Islands for Energy-Constrained NoC Communication
- 2009
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In: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Berlin, Heidelberg : Springer Berlin Heidelberg. ; , s. 183-194
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Conference paper (peer-reviewed)abstract
- An autonomous-DVFS-enabled supply island architecture on network-on-chip platforms is proposed. This architecture exploits the temporal and spatial network traffic variations in minimizing the communication energy while constraining the latency and supply management overhead. Each island is equipped with autonomous DVFS mechanism, which traces the local and nearby network conditions. In quantitative simulations with various types of representative traffic patterns, this approach achieves greater energy efficiency than two other low-energy architectures (typically 10% - 27% lower energy). With autonomous supply management on a proper granularity as demonstrated in this study, the communication energy can be minimized in a scalable manner for many-core NoCs.
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