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1.	Borte, S, et al. (author) Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies 2014 In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 34, s. S185-S185 Journal article (other academic/artistic)
2.	Gernaey, Krist, et al. (author) Conservation principles suspended solids distribution modelling to support ATS introduction on a recirculating WWTP 2004 In: [Host publication title missing]. Conference paper (peer-reviewed)
3.	Holmqvist, Anders, et al. (author) Dynamic Multi-Objective Optimization of Batch Chromatographic Separation Processes 2015 In: Computer Aided Chemical Engineering. - 1570-7946. - 9780444634290 ; 37, s. 815-820 Conference paper (peer-reviewed)abstract This contribution presents a novel offline dynamic multi-objective optimization framework for high-pressure liquid chromatographic (HPLC) processes in batch elution mode. The framework allows for optimization of general elution trajectories parametrized with piecewise constant control signals. It is based on a simultaneous method where both the control and state variables are fully discretized in the temporal domain, using orthogonal collocations on finite elements, and the state variables are discretized in the spatial domain, using a finite volume weighted essentially non-oscillatory (WENO) scheme. The resulting finite dimensional nonlinear program (NLP) is solved using a primal-dual interior point method and automatic differentiation techniques. The advantages of this open-loop optimal control methodology are highlighted through the solution of a challenging ternary complex mixture separation problem for a hydrophobic interaction chromatography (HIC) system. For a bi-objective optimization of the target component productivity and yield, subject to a purity constraint, the set of Pareto solutions generated with general elution trajectories showed considerable improvement in the productivity objective when compared to the Pareto set obtained using conventional linear elution trajectories.

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Type of publication: conference paper (2); journal article (1)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Bryceson, YT (1); Hammarstrom, L (1); Borte, S (1); Nilsson, Bernt (1); Nordenskjold, M (1); von Dobeln, U (1); show more...; Henter, JI (1); Gernaey, Krist V. (1); Magnusson, Fredrik (1); Gernaey, Krist (1); Meeths, M (1); Liebscher, I (1); Krist, K (1); Höök, B. (1); Thornberg, D. (1); Jørgensen, S B (1); Nielsen, M K (1); Munk-Nielsen, T (1); Ingildsen, P (1); Holmqvist, Anders (1); Huusom, Jakob K. (1); Gani, Rafiqul (1); show less...

University: Lund University (2); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Engineering and Technology (2)

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