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  • Renner, Jens, et al. (author)
  • The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin
  • 2005
  • In: Australian Journal of Chemistry. ; 58:2, s. 86-93
  • Journal article (peer-reviewed)abstract
    • Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.
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