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- Ceberg, S., et al.
(författare)
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FLASH radiotherapy and the associated dosimetric challenges
- 2023
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Ingår i: Journal of Physics: Conference Series. ; 2630
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Konferensbidrag (refereegranskat)abstract
- At Lund University and Skåne University Hospital in Lund, Sweden, we have, as the first clinic, modified a clinical Elekta Precise linear accelerator for convertible delivery of ultrahigh dose rate (FLASH) irradiation. Whereas recently published reviews highlighted the need for standardised protocols for ultra-high dose rate beam dosimetry to be able to determine the true potential of FLASH irradiation, several dosimetry studies as well as in-vitro and in-vivo experiments have been carried out at our unit. Dosimetric procedures for verification of accurate dose delivery of FLASH irradiation to cell cultures, zebrafish embryos and small animals have been established using radiochromic films and thermo-luminescent dosimeters. Also, recently the first experience of electron FLASH radiotherapy (FLASH-RT) in canine patients in our clinical setting was published. Our research facilities also include a laboratory for 3D polymer gel manufacturing. Recently, we started investigating the feasibility of a NIPAM polymer gel dosimeter for ultra-high dose rate dosimetry. Furthermore, in the bunker of the modified Elekta linear accelerator, a Surface Guided Radiotherapy (SGRT) system is accessible. The CatalystTM system (C-Rad Positioning, Uppsala, Sweden) provides optical surface imaging for patient setup, real-time motion monitoring and breathing adapted treatment. Aiming at treating patients using ultra-high dose rates, a real-time validation of the alignment between the beam and the target is crucial as the dose is delivered in a fraction of a second. Our research group has during the last decade investigated and developed SGRT workflows which improved patient setup and breathing adapted treatment for several cancer patient groups. Recently, we also started investigating the feasibility of a real-time motion monitoring system for surface guided FLASH-RT. Both FLASH related studies; 3D polymer gel dosimetry and surface guided FLASH-RT are to our knowledge the first of their kind. Following an introduction to the field of FLASH and the associated dosimetric challenges, we here aim to present the two ongoing studies including some preliminary results.
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7th International Workshop on Automotive System/Software Architecture (WASA 2021)
- 2021
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Proceedings (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This volume contains the papers presented at the 7th International Workshop on Automotive System/Software Architecture (WASA 2021) held on March 22, 2021, in Stuttgart, Germany. WASA was organized as part of the 18th IEEE International Conference on Software Architecture (ICSA 2021), the premier software architecture conference. Due to the worldwide SARS-CoV-2 pandemic, the main conference and the workshop were hosted virtually.
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| 4. |
- Bucaioni, Alessio, 1987-, et al.
(författare)
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Joint Workshop on Model-Driven Engineering for Software Architecture (MDE4SA) and International Workshop on Automotive System/Software Architectures (WASA)
- 2023
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Ingår i: Proc. - IEEE Int. Conf. Softw. Archit. Companion, ICSA-C. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665464598 ; , s. 246-247
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Current society heavily relies on software and software systems. Due to its increasing complexity, the design and operation of software systems are becoming challenging. In the last decades, a great deal of effort has been put into addressing software systems design, development, and maintenance challenges. Empirical evidence shows that one of the most critical success factors when developing software systems is their Software Architecture (SA). A SA describes software systems in terms of software components, their interactions, and critical quality attributes. Among other benefits, SAs improve the overall communication among different stakeholders, are the carriers of significant design decisions, promote the use of different abstraction levels, and allow for the early assessment of the software under development.
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| 5. |
- Freislederer, P., et al.
(författare)
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Recent advanced in Surface Guided Radiation Therapy
- 2020
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Ingår i: Radiation oncology (London, England). - : Springer Science and Business Media LLC. - 1748-717X. ; 15:1
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Forskningsöversikt (refereegranskat)abstract
- The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. Although this technology is not new, many aspects of it have only recently been exploited. This review focuses on the latest SGRT developments, both in the field of general clinical applications and special techniques.SGRT has a wide range of applications, including patient positioning with real-time feedback, patient monitoring throughout the treatment fraction, and motion management (as beam-gating in free-breathing or deep-inspiration breath-hold). Special radiotherapy modalities such as accelerated partial breast irradiation, particle radiotherapy, and pediatrics are the most recent SGRT developments.The fact that SGRT is nowadays used at various body sites has resulted in the need to adapt SGRT workflows to each body site. Current SGRT applications range from traditional breast irradiation, to thoracic, abdominal, or pelvic tumor sites, and include intracranial localizations.Following the latest SGRT applications and their specifications/requirements, a stricter quality assurance program needs to be ensured. Recent publications highlight the need to adapt quality assurance to the radiotherapy equipment type, SGRT technology, anatomic treatment sites, and clinical workflows, which results in a complex and extensive set of tests.Moreover, this review gives an outlook on the leading research trends. In particular, the potential to use deformable surfaces as motion surrogates, to use SGRT to detect anatomical variations along the treatment course, and to help in the establishment of personalized patient treatment (optimized margins and motion management strategies) are increasingly important research topics. SGRT is also emerging in the field of patient safety and integrates measures to reduce common radiotherapeutic risk events (e.g. facial and treatment accessories recognition).This review covers the latest clinical practices of SGRT and provides an outlook on potential applications of this imaging technique. It is intended to provide guidance for new users during the implementation, while triggering experienced users to further explore SGRT applications.
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