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1.	Adamina, M, et al. (author) The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study 2022 In: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. - : Wiley. - 1463-1318. ; 24:6, s. 708-726 Journal article (peer-reviewed)
2.	Gerling, M, et al. (author) Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12936- Journal article (peer-reviewed)abstract Nature Communications 7:12321 doi: (2016); Published 5 Aug 2016; Updated 13 Sep 2016 In Fig. 6f of this Article, the labelling of the two immunohistochemistry images was inadvertently changed from ‘Haematoxylin, ki67’ to ‘Haematoxylin, Casp-3’ during the production process. The correct version of Fig.
3.	Gerling, M, et al. (author) Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound 2014 In: Theranostics. - : Ivyspring International Publisher. - 1838-7640. ; 4:6, s. 604-613 Journal article (peer-reviewed)
4.	Gerling, M, et al. (author) Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12321- Journal article (peer-reviewed)abstract A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity is unexpectedly diminished in a mouse model of colitis-associated colon cancer, and that downstream Hh signalling is restricted to the stroma. Functionally, stroma-specific Hh activation in mice markedly reduces the tumour load and blocks progression of advanced neoplasms, partly via the modulation of BMP signalling and restriction of the colonic stem cell signature. By contrast, attenuated Hh signalling accelerates colonic tumourigenesis. In human CRC, downstream Hh activity is similarly reduced and canonical Hh signalling remains predominantly paracrine. Our results suggest that diminished downstream Hh signalling enhances CRC development, and that stromal Hh activation can act as a colonic tumour suppressor.
5.	Hoelzl, MA, et al. (author) Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model 2017 In: Developmental biology. - : Elsevier BV. - 1095-564X .- 0012-1606. ; 429:1, s. 132-146 Journal article (peer-reviewed)
6.	Hoelzl, MA, et al. (author) Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo 2015 In: Stem cells and development. - : Mary Ann Liebert Inc. - 1557-8534 .- 1547-3287. ; 24:21, s. 2547-2560 Journal article (peer-reviewed)
7.	Jonker, MJ, et al. (author) Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs 2013 In: Aging cell. - : Wiley. - 1474-9726 .- 1474-9718. ; 12:5, s. 901-909 Journal article (peer-reviewed)
8.	Keszei, M, et al. (author) Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53± murine model 2018 In: Oncoimmunology. - 2162-4011. ; 7:9, s. e1468954- Journal article (peer-reviewed)
9.	Krishnan, S, et al. (author) Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances 2014 In: The Journal of biological chemistry. - 1083-351X. ; 289:47, s. 32835-44 Journal article (peer-reviewed)
10.	Krishnan, S, et al. (author) Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency 2013 In: The Journal of biological chemistry. - 1083-351X. ; 288:7, s. 5072-5079 Journal article (peer-reviewed)

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Result 1-10 of 21

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Type of publication: journal article (20)

Type of content: peer-reviewed (20)

Author/Editor: Robinson, J. (3); Chen, S. (2); Davies, M. (2); Gupta, S. (2); Lopes, L. (2); Losada, M. (2); show more...; Moss, J. (2); Qureshi, A. (2); Romano, M. (2); Zhang, H. (2); Liu, J. (2); Davies, E. (2); Horn, C. (2); Gupta, A. (2); Liu, T. (2); Martin, J. (2); Aytac, E (2); Ceelen, W (2); Davies, RJ (2); Golda, T (2); Hompes, R (2); Kumar, S (2); Lakkis, Z (2); Park, J (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Wilson, M (2); Baker, A. (2); James, A. (2); Silva, M. (2); Kumar, A. (2); Moore, R. (2); Osman, N. (2); Russ, J. (2); Williams, G. (2); Giraudo, G. (2); Kumar, L. (2); Mahajan, A. (2); Sharma, N. (2); Singh, R. (2); Nowak, K. (2); Costa, M. (2); O'Brien, S. (2); Wood, M (2); Barker, D. (2); Garcia, J. (2); Patel, P. (2); Khan, A. (2); Hunt, L (2); show less...

University: Karolinska Institutet (21)

Language: English (21)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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