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- Kyriazis, Angelos, et al.
(author)
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A MRI and polarized gases compatible respirator and gas administrator for the study of the small animal lung : volume measurement and control
- 2010
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In: IEEE Transactions on Biomedical Engineering. - 1558-2531. ; 57:7, s. 9-1745
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Journal article (peer-reviewed)abstract
- We have developed over the past years an experimental magnetic resonance imaging (MRI) and polarized gases compatible mechanical respirator for the study of the small experimental animal. The respirator has been successfully used for experiments both in the MRI setting for polarized (3)He, (19)F, and proton imaging as well as for functional measurements of the lungs. The new main pneumatic valve with the two integrated sensors for simultaneous lung pressure and volume measurements and the proportional valve to set the tidal volume of the respiration are described. It is shown how the device measures and controls the tidal volume of the lungs.
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| 3. |
- Kyriazis, Angelos, et al.
(author)
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Dynamic ventilation He-3 MRI for the quantification of disease in the rat lung
- 2012
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In: IEEE Transactions on Biomedical Engineering. - 0018-9294 .- 1558-2531. ; 59, s. 777-786
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Journal article (peer-reviewed)abstract
- Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were defined by a rectangular grid that covered the entire rat lung and grew dynamically with it during its inflation. We used regional inflation rate to quantify elastase-induced emphysema and to differentiate healthy ( n8) from elastase-treated ( n9) rat lungs as well as healthy from elastase-treated areas of one rat unilaterally treated with elastase in the left lung. Emphysema was also assessed by gold standard morphological and well-established hyperpolarized He MRI diffusion measurements. Mean values of regional inflation rates were significantly different for healthy and elastase-treated animals and correlated well with the apparent diffusion coefficient of He and morphological measurements. The image-based biomarker inflation rate may be useful for the assessment of regional lung ventilation. © 2011 IEEE.
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| 4. |
- Lagopati, Nefeli, et al.
(author)
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Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer
- 2021
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In: Cancer Genomics & Proteomics. - : Anticancer Research USA Inc.. - 1109-6535 .- 1790-6245. ; 18:3, s. 425-439
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Journal article (peer-reviewed)abstract
- BACKGROUND/AIM: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential.MATERIALS AND METHODS: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection.RESULTS AND CONCLUSION: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.
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