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- Nilsson, Å., et al.
(author)
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Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis : A multicenter study
- 1995
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In: American Journal of Gastroenterology. - 0002-9270 .- 1572-0241. ; 90:3, s. 381-387
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To compare the relapse-preventing effect and the frequency of adverse events of olsalazine and sulphasalazine in sulphasalazine-tolerant patients with ulcerative colitis. METHODS: Patients in remission, with at least two episodes of active disease during the last 5 yr, were randomized to 2 g of sulphasalazine or 1 g of olsalazine daily and were followed for 6-18 months. Relapse rates in the two groups were compared using frequency and life-table analysis. Sixty-nine patients with proctitis, 140 with left-sided colitis, and 113 with subtotal or total colitis were evaluated. RESULTS: In the intention-to-treat analysis, the failure rate (relapses plus withdrawals) was 54.7% in the olsalazine and 47.2% in the sulphasalazine group. In the per-protocol analysis excluding withdrawals, 44.7% relapsed in the olsalazine and 39.3% in the sulphasalazine group. Remission curves did not differ significantly, although at all time intervals the frequency of remission was slightly higher in the sulphasalazine group (p = 0.19 in the intention-to-treat analysis and p = 0.42 in the per-protocol analysis estimated by the log-rank test). Twelve patients (of whom five had diarrhea) in the olsalazine group versus eight patients in the sulphasalazine group discontinued the study because of side effects. CONCLUSION: The relapse-preventing effect of olsalazine and sulphasalazine in sulphasalazine-tolerant patients did not differ. Furthermore, the tolerability of olsalazine, particularly concerning diarrhea, appears to be better than previously reported.
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- Ekdahl, K N, et al.
(author)
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Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.
- 1991
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In: Gastroenterology. - 0016-5085 .- 1528-0012. ; 101:4, s. 1076-1082
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Journal article (peer-reviewed)abstract
- Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis.
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- Landahl, Jonas, 1986, et al.
(author)
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Towards Adopting Digital Twins to Support Design Reuse during Platform Concept Development
- 2018
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In: Proceedings of NordDesign: Design in the Era of Digitalization, NordDesign 2018.
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Conference paper (peer-reviewed)abstract
- To gain a first-mover advantage on the marketplace, manufacturers are striving to develop innovative products that meet the needs of a wide range of customers. Traditionally to support innovative design, the fuzzy concept stage has long been supported by heuristic design philosophies. In recent years, new supportive technologies have enabled concept generation based on the collection and reuse of existing data. Existing data can be collected from various sources; for example, customer reviews, historical data, or by studying existing products or other industrial assets such as production machines and tooling. Lately, the concept of Digital Twin (DT) has gained a wealth of attention as a means to construct a high-fidelity digital copy of a physical asset and to study its shape, position, gesture, status and motion. The common aim of the DT is to support the realistic model of system behavior that can support performance prediction and optimization. However, in providing sufficient support during the conceptual stages the realistic models become heavy and costly to adapt. While the emerging data-driven design approaches can be used to generate designs with alterations, there is a lack of support to generate and evaluate solutions during the conceptual stages. In this paper, a framework of a Digital Platform Twin (DPT) is proposed to fill this gap. In contrast to a sole high-fidelity digital representation, the DPT builds on abstracting multiple high-fidelity Digital Twins into a low- fidelity platform model, represented as a function model. The DPT framework proclaims the vision of supporting design engineers in the process of abstracting functionalities of existing assets, inserting new functionalities and technologies in the function structure to ultimately support the generation and evaluation of new functional concepts. To demonstrate the DPT framework, an automotive example is presented. We believe that reuse during platform concept development can be supported with the use of multiple DTs. To achieve this, a challenge is to practically realize the transcending in abstraction levels of the models: from Digital Twins to function model and from function model to geometry models. The transcending in abstraction levels is therefore a matter of future work.
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- Larsson, D. G. Joakim, 1969, et al.
(author)
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Läkemedel i miljön
- 2014
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In: Läkemedelsboken 2014. ; , s. 1267-1279
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Research review (peer-reviewed)
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