| 1. |
- Janunger, Tomas, et al.
(author)
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A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33.
- 2009
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In: Neurology. - 0028-3878 .- 1526-632X. ; 73:21, s. 1767-1773
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Journal article (peer-reviewed)abstract
- OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
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| 2. |
- Wosinska, Lena, et al.
(author)
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Network resilience in future optical networks
- 2009
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In: Towards Digital Optical Networks. - Berlin, Heidelberg : Springer. - 3642015239 - 9783642015236 ; , s. 253-284
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Conference paper (peer-reviewed)abstract
- Network resilience is an issue of deep concern to network operators being eager to deploy high-capacity fibre networks, since a single failure in the network could result in significant losses of revenue. The importance of network reliability will keep pace with the steadily increasing network capacity. For very-high-capacity future optical networks, carrying multitudes of 10 Gbit/s channels per fibre strand, a failure of optical connection will interrupt a vast amount of services running on-line, making the connection availability a factor of great significance. Therefore the ultrahigh capacity future optical networks will face a challenge of providing very efficient and fast survivability mechanisms. In this chapter we review the terminology and basic resilience techniques along with the results of research work on optical network survivability performed in the frame of COST291 cooperation. Our research work was focused on reliability performance improvement and on recovery in multilayer optical networks.
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