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- Eriksson, J, et al.
(author)
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Stated preferences for relapsed or refractory mantle cell lymphoma treatments in Sweden and Germany
- 2020
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In: Future oncology (London, England). - : Future Medicine Ltd. - 1744-8301 .- 1479-6694. ; 16:13, s. 859-868
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Journal article (peer-reviewed)abstract
- Background: We aimed to elicit treatment preferences in relapsed/refractory mantle cell lymphoma (r/r MCL). Materials & methods: A discrete-choice experiment comprising six attributes (‘overall survival’, ‘progression-free survival’, ‘fatigue’, ‘nausea’, ‘risk of serious infections’ and ‘treatment administration’) was administered to r/r MCL patients, physicians and the general population (GP) in Sweden and Germany. Results: 18 patients, 68 physicians and 191 GP members participated. ‘Overall survival’ was the most important attribute, followed by ‘risk of serious infection’ and ‘progression-free survival’ among physicians and the GP. In contrast, ‘treatment administration’ was the second most important attribute to patients, followed by ‘risk of serious infection.’ Conclusion: Preferences for characteristics differentiating treatments of r/r MCL varies between patients, physicians and members of the GP.
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- Landfeldt, E, et al.
(author)
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Sick leave and disability pension before and after diagnosis of multiple sclerosis
- 2016
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In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 22:14, s. 1859-1866
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Journal article (peer-reviewed)abstract
- Multiple sclerosis (MS) is associated with considerable morbidity and serious disability, but little is known of the long-term impact of the disease on work ability. Objectives: To assess sick leave (short-term absence) and disability pension (long-term absence) before and after diagnosis of MS. Methods: Patients with MS in Sweden were identified in a nationwide disease-specific register and matched with general population controls. Sick leave and disability pension were measured before and after index (i.e. the MS diagnosis date). Results: The final sample comprised 6092 patients and 60,345 controls (mean age 39 years; 70% female). The mean annual prevalence of sick leave ranged from 12% the first year after index to 23% after 11 years among patients and from 13% to 13% among controls. Corresponding estimates for disability pension were 12% and 55% for patients and 7% and 9% for controls. Significant differences in sick leave were observed up to 15 years before index and 3 years for disability pension. Conclusion: Patients with MS in Sweden have elevated levels of sick leave and disability pension up to 15 years before disease diagnosis. Our results highlight the burden of disease on affected patients and society and underscore the substantial unmet medical need.
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