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1.	Gartland, M, et al. (author) AVANTI 2. Randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus indinavir in HIV-infected antiretroviral-naive patients 2000 In: AIDS (London, England). - 0269-9370. ; 14:4, s. 367-374 Journal article (peer-reviewed)
2.	Miller, V, et al. (author) Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management: recommendations for the European setting. The EuroGUidelines Group for HIV resistance 2001 In: AIDS (London, England). - : Ovid Technologies (Wolters Kluwer Health). - 0269-9370. ; 15:3, s. 309-320 Journal article (peer-reviewed)
3.	Vandamme, AM, et al. (author) Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up 2001 In: Antiviral therapy. - 1359-6535. ; 6:1, s. 21-39 Journal article (peer-reviewed)
4.	Lennerstrand, Johan, et al. (author) Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine 2001 In: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 45:7, s. 2144-2146 Journal article (peer-reviewed)abstract We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate.
5.	Lennerstrand, Johan, et al. (author) Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants 2001 In: Journal of Virology. - 0022-538X .- 1098-5514. ; 75:15, s. 7202-7205 Journal article (peer-reviewed)abstract Using a large panel of human immunodeficiency virus type 1 site-directed mutants, we have observed a higher correlation than has previously been demonstrated between zidovudine (AZT)-triphosphate resistance data at the reverse transcriptase (RT) level and corresponding viral AZT resistance. This enhanced-resistance effect at the RT level was seen with ATP and to a lesser extent with PP(i) when ATP was added at physiological concentrations. The ATP-dependent mechanism (analogous to pyrophosphorolysis) appears to be dominant in the mutants bearing the D67N and K70R or 69 insertion mutations, whereas the Q151M mutation seems independent of ATP for decreased binding to AZT-triphosphate.

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Type of publication: journal article (5)

Type of content: peer-reviewed (5)

Author/Editor: Clotet, B (3); Sonnerborg, A (2); Schmit, JC (2); Vandamme, AM (2); Clumeck, N (2); Lange, J (2); show more...; Vella, S (2); Pillay, D (2); Miller, V (2); Lennerstrand, Johan (2); Schuurman, R (2); Giaquinto, C (1); Johnson, M. (1); Hall, W (1); Phillips, A. (1); Sandstrom, E (1); Cooper, DA (1); Gatell, J (1); Goebel, F (1); Reiss, P (1); Yeo, J (1); Chodakewitz, J (1); Gartland, M (1); Gazzard, B (1); Katlama, C (1); Perrin, L (1); Soriano, V (1); Darbyshire, J (1); Moore, S. (1); Patel, K (1); Moroni, M (1); Mulcahy, F (1); Montaner, J. (1); Williams, A (1); Lundgren, J (1); GERSTOFT, J (1); Hatzakis, A (1); Dedes, N (1); Maguire, M (1); Watkins, K (1); Clavel, F (1); Leal, M (1); Camacho, R (1); Colebunders, R (1); Loveday, C (1); Goebel, FD (1); Hug, M (1); Boucher, C (1); Coughlan, M (1); Rachlis, A. (1); show less...

University: Karolinska Institutet (3); Uppsala University (2)

Language: English (5)

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