| 1. |
- Abarenkov, Kessy, et al.
(author)
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Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard – a report from a May 23-24, 2016 workshop (Gothenburg, Sweden)
- 2016
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In: MycoKeys. - : Pensoft Publishers. - 1314-4057 .- 1314-4049. ; 16, s. 1-15
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Journal article (peer-reviewed)abstract
- Recent molecular studies have identified substantial fungal diversity in indoor environments. Fungi and fungal particles have been linked to a range of potentially unwanted effects in the built environment, including asthma, decay of building materials, and food spoilage. The study of the built mycobiome is hampered by a number of constraints, one of which is the poor state of the metadata annotation of fungal DNA sequences from the built environment in public databases. In order to enable precise interrogation of such data – for example, “retrieve all fungal sequences recovered from bathrooms” – a workshop was organized at the University of Gothenburg (May 23-24, 2016) to annotate public fungal barcode (ITS) sequences according to the MIxS-Built Environment annotation standard (http://gensc.org/mixs/). The 36 participants assembled a total of 45,488 data points from the published literature, including the addition of 8,430 instances of countries of collection from a total of 83 countries, 5,801 instances of building types, and 3,876 instances of surface-air contaminants. The results were implemented in the UNITE database for molecular identification of fungi (http://unite.ut.ee) and were shared with other online resources. Data obtained from human/animal pathogenic fungi will furthermore be verified on culture based metadata for subsequent inclusion in the ISHAM-ITS database (http://its.mycologylab.org).
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| 2. |
- Appelgren, Patrik, et al.
(author)
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Disruption mechanisms in electrified solid copper jets
- 2011
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In: Journal of applied mechanics. - : ASME International. - 0021-8936 .- 1528-9036. ; 78:2
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Journal article (peer-reviewed)abstract
- Interaction between a solid copper jet and an electric current pulse is a complex process that has been experimentally studied by letting a jet created by a shaped charge device pass through an electrode configuration consisting of two aluminum plates with a separation distance of 150 mm. When the jet bridged the electrodes, which are connected to a charged pulsed power supply, current pulses with amplitude up to 250 kA were passed through the jet. By using flash X-ray diagnostics, the disruption of the electrified jets could be studied. In this paper, the disruption of the electrified jets is discussed and compared with disruption phenomena observed in electrically exploded metal rods in a static setup. Necks are naturally formed along a stretching jet, and in the experiments with current interaction these necks explode electrically. In the static experiments, the metal rods have small notches distributed along the rod to resemble the necks of the jet. When two neighboring necks or notches explode, the shock of the explosion compresses the intermediate jet or rod segment axially and the material is forced out radially. The disruption phenomena in the jet and rod experiments are similar with rapid expansion of the metal at explosion and at comparable velocities.
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| 3. |
- Appelgren, Patrik, et al.
(author)
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Experimental Study of Electromagnetic Effects on Solid Copper Jets
- 2010
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In: Journal of applied mechanics. - : ASME International. - 0021-8936 .- 1528-9036. ; 77:1, s. 011010-
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Journal article (peer-reviewed)abstract
- In this paper we present a study of the interaction between all electric current pulse and a solid copper jet. Experiments were performed using a dedicated pulsed power supply delivering a current pulse of such amplitude, rise little, and duration that the jet is efficiently affected. The copper jet was created by using a shaped charge warhead. All electrode configuration consisting of two aluminum plates with a separation distance of 150 mm was used. The discharge current pulse and the voltages at the capacitors and at the electrodes were measured to obtain data oil energy deposition in and the resistance of the jet and electrode contact region. X-ray diagnostics were used to radiograph the jet, and by analyzing the radiograph, the degree of disruption of the electrified jet could be obtained. It was found that a current pulse with an amplitude of 200-250 kA and a rise time of 16 mu s could strongly enhance the natural fragmentation of the jet. In this case, the initial electric energy was 100 kJ and about 90% of the electric energy was deposited in the jet and electrodes. At the exit of the electrode region, the jet fragments formed rings with a radial velocity of up to 200 m/s, depending oil the initial electric energy in the pulsed power supply. [DOI: 10.1115/1.3172251]
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| 4. |
- Appelgren, Patrik, et al.
(author)
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Interaction between solid copper jets and powerful electrical current pulses
- 2011
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In: Journal of applied mechanics. - : ASME International. - 0021-8936 .- 1528-9036. ; 78:2
-
Journal article (peer-reviewed)abstract
- The interaction between a solid copper jet and an electric current pulse is studied. Copper jets that were created by a shaped-charge device were passed through an electrode configuration consisting of two aluminum plates with a separation distance of 150 mm. The electrodes were connected to a pulsed-power supply delivering a current pulse with amplitudes up to 250 kA. The current and voltages were measured, providing data on energy deposition in the jet and electrode contact region, and flash X-ray diagnostics were used to depict the jet during and after electrification. The shape of, and the velocity distributions along, the jet has been used to estimate the correlation between the jet mass flow through the electrodes and the electrical energy deposition. On average, 2.8 kJ/g was deposited in the jet and electrode region, which is sufficient to bring the jet up to the boiling point. A model based on the assumption of a homogenous current flow through the jet between the electrodes underestimates the energy deposition and the jet resistance by a factor 5 compared with the experiments, indicating a more complex current flow through the jet. The experimental results indicate the following mechanism for the enhancement of jet breakup. When electrified, the natural-formed necks in the jet are subjected to a higher current density compared with other parts of the jet. The higher current density results in a stronger heating and a stronger magnetic pinch force. Eventually, the jet material in the neck is evaporated and explodes electrically, resulting in a radial ejection of vaporized jet material.
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| 5. |
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| 6. |
- Appelgren, Patrik, et al.
(author)
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Studies of Electrically-Exploded Conductors for Electric Armour Applications
- 2009
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In: Acta Physica Polonica. A. - 0587-4246 .- 1898-794X. ; 115:6, s. 1072-1074
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Journal article (peer-reviewed)abstract
- This paper presents experimental studies of current interaction with static copper rods. The results of the static experiments are used to discuss the effects responsible for the disruption of shaped-charge jets in electric armour. These effects include ohmic heating of, and current diffusion into, the rod as well as radial magnetic forces.
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| 7. |
- Björnsson, Jon Mar, et al.
(author)
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Reduced proliferative capacity of hematopoietic stem cells deficient in hoxb3 and hoxb4
- 2003
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In: Blood. - 0006-4971 .- 1528-0020. ; 23:11, s. 3872-3883
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Journal article (peer-reviewed)abstract
- Several homeobox transcription factors, such as HOXB3 and HOXB4, have been implicated in regulation of hematopoiesis. In support of this, studies show that overexpression of HOXB4 strongly enhances hematopoietic stem cell regeneration. Here we find that mice deficient in both Hoxb3 and Hoxb4 have defects in endogenous hematopoiesis with reduced cellularity in hematopoietic organs and diminished number of hematopoietic progenitors without perturbing lineage commitment. Analysis of embryonic day 14.5 fetal livers revealed a significant reduction in the hematopoietic stem cell pool, suggesting that the reduction in cellularity observed postnatally is due to insufficient expansion during fetal development. Primitive Lin(-) Scal(+) c-kit(+) hematopoietic progenitors lacking Hoxb3 and Hoxb4 displayed impaired proliferative capacity in vitro. Similarly, in vivo repopulating studies of Hoxb3/Hoxb4-deficient hematopoietic cells resulted in lower repopulating capability compared to normal littermates. Since no defects in homing were observed, these results suggest a slower regeneration of mutant HSC. Furthermore, treatment with cytostatic drugs demonstrated slower cell cycle kinetics of hematopoietic stem cells deficient in Hoxb3 and Hoxb4, resulting in increased tolerance to antimitotic drugs. Collectively, these data suggest a direct physiological role of Hoxb4 and Hoxb3 in regulating stem cell regeneration and that these genes are required for maximal proliferative response.
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| 8. |
- Hellberg, Christel, et al.
(author)
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Evidence and evidence gaps in assessments and interventions in areas related to social work research and practice – an overview of four evidence maps : [Vetenskapligt kunskapsläge om utredning och insatser i socialt arbete och forskning –en sammanställning av fyra kartläggningar]
- 2023
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In: European Journal of Social Work. - : Informa UK Limited. - 1369-1457 .- 1468-2664. ; 26:5, s. 882-895
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Journal article (peer-reviewed)abstract
- This overview of four evidence maps is based on systematic reviews of assessment and interventions in social work practice. The aim was to investigate the evidence and evidence gaps within four important areas for social work research and practice. Descriptive data on search strategies and domains were collected from four evidence maps, on Social Assistance, Substance Dependence, Care for older adults respectively for persons with disabilities. The scientific quality and scientific evidence were assessed. Key findings were summarised by analyzing and discussing common and specific elements in the evidence maps. The overview was undertaken in close collaboration between researchers with expertise in the field and a government agency. The overview identified both evidence and evidence gaps with respect to effects and experiences of interventions and assessment methods in four evidence maps. Evidence maps provide a comprehensive picture of the state of social services research and can thereby be of use to both researchers and practitioners, and in the production of evidence based social work.
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| 9. |
- Knief, Ulrich, et al.
(author)
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Highly pathogenic avian influenza causes mass mortality in Sandwich Tern Thalasseus sandvicensis breeding colonies across north-western Europe
- 2024
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In: Bird conservation international. - : Cambridge University Press. - 0959-2709 .- 1474-0001. ; 34
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Journal article (peer-reviewed)abstract
- In 2022, highly pathogenic avian influenza (HPAI) A(H5N1) virus clade 2.3.4.4b became enzootic and caused mass mortality in Sandwich TernThalasseus sandvicensis and other seabird species across north-western Europe. We present data on the characteristics of the spread of the virus between and within breeding colonies and the number of dead adult Sandwich Terns recorded at breeding sites throughout north-western Europe. Within two months of the first reported mortalities, 20,531 adult Sandwich Terns were found dead, which is >17% of the total north-western European breeding population. This is probably an under-representation of total mortality, as many carcasses are likely to have gone unnoticed and unreported. Within affected colonies, almost all chicks died. After the peak of the outbreak, in a colony established by late breeders, 25.7% of tested adults showed immunity to HPAI subtype H5. Removal of carcasses was associated with lower levels of mortality at affected colonies. More research on the sources and modes of transmission, incubation times, effective containment, and immunity is urgently needed to combat this major threat for colonial seabirds.
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| 10. |
- Larsson, Tobias, et al.
(author)
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Project: ProViking THINK - Team för Heterogen Innovationskunskap
- 2008
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Other publication (pop. science, debate, etc.)abstract
- Begreppet product-service systems (PSS), eller funktionella produkter, förutspås ha betydande påverkan för ett framtida hållbart samhälle. Ett PSS-synsätt kommer att förändra hur produkter och tjänster används, men också förändra tillvägagångssättet i utvecklingen, eftersom ansvaret för den fysiska produkten genom hela dess livscykel kvarstår hos företaget eller konsortiet som utvecklar PSS-lösningen. I och med detta kan aktiviteterna med omkonstruktion, återanvändning och återvinning, utföras på ett totalt annorlunda sätt än i dag. I den här situationen blir kapaciteten att ständigt förbättra kundupplevt värde genom nya lösningar en viktig förmåga. Således står utvecklingsteam idag inför två stora utmaningar; dels ska de kunna hantera mer abstrakta kundbehov, dels ska de på ett effektivt sätt ständigt bidra till nya lösningar. Det här projektets mål är att stödja PSS-utvecklingsteamets innovationsprocess genom att föreslå faciliterande metoder och verktyg. Specifikt fokus ligger på följande aspekter för att bidra till utvecklingen av en sammanhängande metodologi för team-baserad innovation:- Identifiering, analys och kommunikation av kundbehov samt modellering av värde- Tvärfunktionella team- Effektiv kunskapsdelning- Modellering och visualisering av lösningar baserat på ett kunskapslivscykel perspektiv Projektet kommer att vara en gemensam prestation av industri- och akademirepresentanter. Det praktiska arbetet kommer att utföras i ett nära samarbete. I stort vägleds projektet av antagandet att – visualisering av affärs- och utvecklingsrelaterad kunskap samt snabba modellerings- och simuleringsmöjligheter i tidiga faser stödjer PSS-teamets förmåga att finna nya lösningar och genomföra hållbar utveckling. Förutom ökad kunskap om strategier och tillvägagångssätt för team-baserad innovation kommer demonstratorer av verktyg och metoder vara ett resultat av projektarbetet.
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