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- Bomben, Riccardo, et al.
(author)
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Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia : an Italian multicenter study
- 2007
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 109:7, s. 2989-2998
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Journal article (peer-reviewed)abstract
- IGHV3-21-using chronic lymphocytic leukemia (CLL) is a distinct entity with restricted immunoglobulin gene features and poor prognosis and is more frequently encountered in Northern than Southern Europe. To further investigate this subset and its geographic distribution in the context of a country (Italy) with both continental and Mediterranean areas, 37 IGHV3-21 CLLs were collected out of 1076 cases enrolled by different institutions from Northern or Central Southern Italy. Of the 37 cases, 18 were identified as homologous (hom)HCDR3-IGHV3-21 CLLs and were found almost exclusively (16 of 18) in Northern Italy; in contrast, 19 nonhomHCDR3-IGHV3-21 cases were evenly distributed throughout Italy. Clinically, poor survivals were documented for IGHV3-21 CLLs as well as for subgroups of mutated and homHCDR3-IGHV3-21 CLLs. Negative prognosticators CD38, ZAP-70, CD49d, and CD79b were expressed at higher levels in homHCDR3 than nonhomHCDR3-IGHV3-21 cases. Differential gene expression profiling (GEP) of 13 IGHV3-21 versus 52 non-IGHV3-21 CLLs identified, among 122 best-correlated genes, TGFB2 and VIPR1 as down- and up-regulated in IGHV3-21 CLL cases, respectively. Moreover, GEP of 7 homHCDR3 versus 6 nonhomHCDR3-IGHV3-21 CLLs yielded 20 differentially expressed genes, with WNT-16 being that expressed at the highest levels in homHCDR3-IGHV3-21 CLLs. Altogether, IGHV3-21 CLLs, including those with homHCDR3, had a peculiar global phenotype in part explaining their worse clinical outcome.
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2. |
- Corsini, Filippo, et al.
(author)
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The Advent of Practice Theories in Research on Sustainable Consumption: Past, Current and Future Directions of the Field
- 2019
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In: Sustainability. - : MDPI AG. - 2071-1050. ; 11:2
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Journal article (peer-reviewed)abstract
- The application of practice theories in the domain of sustainability research in consumer studies is increasingly advocated based on the premise that this allows to analyse consumption as a social phenomenon. Consequently, the applications of social practice theories to this field are expanding geometrically and to date, little retrospective work on this evolution has been made. We conduct a bibliometric analysis of applications of practice theories in the domain of sustainability research in consumer studies. Our results show a temporal succession of research trends: ‘consumer identity’ dominated the field between 2009 and 2012, ‘business and governance’ between 2012 and 2014, ‘sustainable consumption and production’ between 2013 and 2014, ‘urban living and policy’ between 2014 and 2015 and ‘household energy’ from 2015 until the present. We see a high potential of future applications of practice theories in the fields of the sharing and circular economy, as well as in research on smart cities. We provide new insights into the evolution and future trends of applications of social practice theory to domains that are relevant for research on sustainability and consumer studies
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