| 1. |
- Hudson, Lawrence N, et al.
(author)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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In: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Journal article (peer-reviewed)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 2. |
- De Palma, Adriana, et al.
(author)
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Predicting bee community responses to land-use changes : effects of geographic and taxonomic biases
- 2016
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6, s. 1-14
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Journal article (peer-reviewed)abstract
- Land-use change and intensification threaten bee populations worldwide, imperilling pollination services. Global models are needed to better characterise, project, and mitigate bees' responses to these human impacts. The available data are, however, geographically and taxonomically unrepresentative; most data are from North America and Western Europe, overrepresenting bumblebees and raising concerns that model results may not be generalizable to other regions and taxa. To assess whether the geographic and taxonomic biases of data could undermine effectiveness of models for conservation policy, we have collated from the published literature a global dataset of bee diversity at sites facing land-use change and intensification, and assess whether bee responses to these pressures vary across 11 regions (Western, Northern, Eastern and Southern Europe; North, Central and South America; Australia and New Zealand; South East Asia; Middle and Southern Africa) and between bumblebees and other bees. Our analyses highlight strong regionally-based responses of total abundance, species richness and Simpson's diversity to land use, caused by variation in the sensitivity of species and potentially in the nature of threats. These results suggest that global extrapolation of models based on geographically and taxonomically restricted data may underestimate the true uncertainty, increasing the risk of ecological surprises.
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| 3. |
- Gremel, G., et al.
(author)
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Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma
- 2011
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 105:4, s. 565-574
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Journal article (peer-reviewed)abstract
- BACKGROUND: The homeobox containing transcription factor MSX2 is a key regulator of embryonic development and has been implicated to have a role in breast and pancreatic cancer. METHODS: Using a selection of two-and three-dimensional in vitro assays and tissue microarrays (TMAs), the clinical and functional relevance of MSX2 in malignant melanoma was explored. A doxycyline-inducible over-expression system was applied to study the relevance of MSX2 in vitro. For TMA construction, tumour material from 218 melanoma patients was used. RESULTS: Ectopic expression of MSX2 resulted in the induction of apoptosis and reduced the invasive capacity of melanoma cells in three-dimensional culture. MSX2 over-expression was shown to affect several signalling pathways associated with cell invasion and survival. Downregulation of N-Cadherin, induction of p21 and inhibition of both BCL2 and Survivin were observed. Cytoplasmic MSX2 expression was found to correlate significantly with increased recurrence-free survival (P = 0.008). Nuclear expression of MSX2 did not result in significant survival correlations, suggesting that the beneficial effect of MSX2 may be independent of its DNA binding activity. CONCLUSIONS: MSX2 may be an important regulator of melanoma cell invasion and survival. Cytoplasmic expression of the protein was identified as biomarker for good prognosis in malignant melanoma patients.
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| 5. |
- Healey, Patrick G. T., et al.
(author)
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When Words Fail: Collaborative Gestures During Clarification Dialogues
- 2015
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In: Turn-Taking and Coordination in Human-Machine Interaction. Papers from the 2015 AAAI Spring Symposium, March 23–25 2015, Palo Alto, USA. - 9781577357117 ; , s. 23-29
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Conference paper (peer-reviewed)abstract
- Research on co-speech gestures has primarily focussed on speakers. However, in conversation non-speaking addressees can also gesture. Often this is to provide concurrent feedback such as backchannels but sometimes it involves gestures that relate to the specific content of the speaker's turn. We hypothesise that non-speakers should contribute most actively during clarification sequences i.e. at the moments when mutual-understanding is threatened. We test this hypothesis using a corpus of story-telling dialogues, captured using video and motion capture. The results show that during clarification sequences speaker and non-speaker behaviours tend to merge. Non-speakers in particular move their hands faster and produce more than twice as many content-specific specific gestures in overlap with speaker turns. These results underline the collaborative nature of conversation, the strategic importance of non-verbal resources for sustaining mutual-understanding and the critical role of clarification and repair in successful communication.
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| 8. |
- Howes, Christine, 1978, et al.
(author)
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Gesture, self-repair and reasoning in schizophrenia
- 2016
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In: Languages as Mechanisms for Interaction : Explorations and Repercussions. Workshop at Ghent University 24 th - 25 th of June, 2016, Ghent, Belgium.
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Conference paper (other academic/artistic)
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| 9. |
- Howes, Christine, 1978, et al.
(author)
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Helping hands? Gesture and self-repair in schizophrenia
- 2016
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In: LREC-2016 Workshop: Resources and processing of linguistic and extra-linguistic data from people with various forms of cognitive/psychiatric impairments. RaPID-2016, 23rd of May 2016 - Portorož, Slovenia / Editor(s): Dimitrios Kokkinakis. - Linköping : Linköping University Electronic Press, Linköpings universitet. - 1650-3686 .- 1650-3740. - 9789176857304
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Conference paper (peer-reviewed)
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