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1.	Bresters, D, et al. (author) Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years: TBI is what really matters 2016 In: Bone marrow transplantation. - : Springer Science and Business Media LLC. - 1476-5365 .- 0268-3369. ; 51:11, s. 1482-1489 Journal article (peer-reviewed)
2.	Rousset, C. I., et al. (author) A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice 2015 In: Journal of Neurochemistry. - : Wiley. - 0022-3042. ; 133:2, s. 242-252 Journal article (peer-reviewed)abstract Perinatal hypoxic-ischaemic encephalopathy (HIE) occurs in 1-2 in every 1000 term infants and the devastating consequences range from cerebral palsy, epilepsy and neurological deficit to death. Cellular damage post insult occurs after a delay and is mediated by a secondary neural energy failure. AMP-activated protein kinase (AMPK) is a sensor of cellular stress resulting from ATP depletion and/or calcium dysregulation, hallmarks of the neuronal cell death observed after HIE. AMPK activation has been implicated in the models of adult ischaemic injury but, as yet, there have been no studies defining its role in neonatal asphyxia. Here, we find that in anin vivo model of neonatal hypoxia-ischaemic and in oxygen/glucose deprivation in neurons, there is pathological activationof the calcium/calmodulin-dependent protein kinase kinase (CaMKK)-AMPK1 signalling pathway. Pharmacological inhibition of AMPK during the insult promotes neuronal survival but, conversely, inhibiting AMPK activity prior to the insult sensitizes neurons, exacerbating cell death. Our data have pathological relevance for neonatal HIE as prior sensitization such as exposure to bacterial infection (reported to reduce AMPK activity) produces a significant increase in injury.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Jenkins, A. (1); Lutz, P. (1); Diaz, MA (1); Hagberg, Henrik, 195 ... (1); Gressens, P (1); Sundin, M. (1); show more...; Bresters, D (1); Vettenranta, K. (1); Faraci, M (1); Bader, P (1); Dalissier, A (1); Potschger, U (1); Michel, G (1); Skinner, R (1); Peters, C. (1); Sedlacek, P (1); Shaw, PJ (1); Gibson, B (1); Thornton, C. (1); Lawitschka, A (1); Carling, D (1); Versluys, AB (1); Cugno, C (1); Al-Seraihy, A (1); Leiper, A (1); O'Brien, TA (1); Salooja, N (1); Rousset, C. I. (1); Kichev, A. (1); Leiper, F. C. (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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