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- Karpanen, Terhi, et al.
(author)
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Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
- 2008
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In: Circulation Research. - : American Heart Association. - 0009-7330 .- 1524-4571. ; 103:9, s. 1018-1026
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Journal article (peer-reviewed)abstract
- Vascular endothelial growth factor (VEGF)-B is poorly angiogenic but prominently expressed in metabolically highly active tissues, including the heart. We produced mice expressing a cardiac-specific VEGF-B transgene via the alpha-myosin heavy chain promoter. Surprisingly, the hearts of the VEGF-B transgenic mice showed concentric cardiac hypertrophy without significant changes in heart function. The cardiac hypertrophy was attributable to an increased size of the cardiomyocytes. Blood capillary size was increased, whereas the number of blood vessels per cell nucleus remained unchanged. Despite the cardiac hypertrophy, the transgenic mice had lower heart rate and blood pressure than their littermates, and they responded similarly to angiotensin II-induced hypertension, confirming that the hypertrophy does not compromise heart function. Interestingly, the isolated transgenic hearts had less cardiomyocyte damage after ischemia. Significantly increased ceramide and decreased triglyceride levels were found in the transgenic hearts. This was associated with structural changes and eventual lysis of mitochondria, resulting in accumulation of intracellular vacuoles in cardiomyocytes and increased death of the transgenic mice, apparently because of mitochondrial lipotoxicity in the heart. These results suggest that VEGF-B regulates lipid metabolism, an unexpected function for an angiogenic growth factor.
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| 3. |
- Drobac, Senka, et al.
(author)
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The Labourious Cleaning : Acquiring and Transforming 19th-Century Epistolary Metadata
- 2023
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In: DHNB2023 Conference Proceedings. - Oslo.
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Conference paper (peer-reviewed)abstract
- The paper documents the process of collecting, consolidating, and publishing epistolary metadata from Finnish cultural heritage organizations to create an archive for bottom-up analyses of 19th-century epistolary culture. We describe and discuss the data survey that was conducted to gather information about available letter collections across Finland, as well as the cleaning and harmonizing of over 350,000 letters from twelve different sources in various digital formats. We have also developed a data model that combines event-based and letter-based aspects of the metadata. Furthermore, the paper contributes tothe ongoing discussion of the initial phases of data-intensive research and the importance of discussing the labor of cleaning data. We believe that our experiences described in this paper can have wider significance for other digital humanities projects in Europe.
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| 4. |
- Tuominen, Jouni, et al.
(author)
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Constellations of Correspondence : A Linked Data Service and Portal for Studying Large and Small Networks of Epistolary Exchange in the Grand Duchy of Finland
- 2022
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In: Proceedings of the 6th Digital Humanities in the Nordic and Baltic Countries Conference (DHNB 2022). ; , s. 415-423
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Conference paper (peer-reviewed)abstract
- This paper presents the vision of aggregating, harmonizing, and publishing letter catalog metadata (information e.g. of senders, receivers and datings of letters) from cultural heritage (CH) institutions in Finland as a single reconciled Linked Open Data (LOD) service and a semantic portal providing data analytical tools for researchers. The research is conducted as part of the consortium research project Constellations of Correspondence (CoCo). The target of the project is to study – for the first time – scattered, heterogeneous epistolary metadata regarding the period of the Grand Duchy of Finland (1809–1917) as one, integrated dataset and make it interoperable and available. This will enable scholars to ask ambitious research questions in the field of computer science and to conduct empirical, bottom-up case studies e.g. on epistolary culture, communicative networks, and heritagization processes. This paper discusses one of the first datasets acquired by the project, the letter collection of the Board of the Finnish Art Society (1846–1901), provided by the Finnish National Gallery, which contains details of c. 1150 letters sent or received by c. 400 actors.
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