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Search: WFRF:(Lesma G)

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1.
  • Danieli, B, et al. (author)
  • Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
  • 2004
  • In: Chemistry and Biodiversity. - : Wiley. - 1612-1872 .- 1612-1880. ; 1:2, s. 327-345
  • Journal article (peer-reviewed)abstract
    • The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Sterner, Olov (1)
NORSTEDT, G (1)
Nystrom, T (1)
Alkharusi, A (1)
Lesma, E (1)
Ancona, S (1)
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Chiaramonte, E (1)
Gorio, A (1)
Appendino, G (1)
Noncovich, A (1)
Fontana, G (1)
Bombardelli, E (1)
Silvani, A (1)
Danieli, B (1)
Giardini, A (1)
Lesma, G (1)
Passarella, D (1)
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University
Lund University (1)
Karolinska Institutet (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (1)

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