| 1. |
- Zhuang, Ting, et al.
(author)
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SHARPIN stabilizes estrogen receptor a and promotes breast cancer cell proliferation
- 2017
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:44, s. 77137-77151
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Journal article (peer-reviewed)abstract
- Estrogen receptor a is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. In our study, we identified the novel E3 ubiquitin ligase SHARPIN function to facilitate ERα signaling. SHARPIN is highly expressed in human breast cancer and correlates with ERα protein level by immunohistochemistry. SHARPIN expression level correlates with poor prognosis in ERα positive breast cancer patients. SHARPIN depletion based RNA-sequence data shows that ERα signaling is a potential SHARPIN target. SHARPIN depletion significantly decreases ERα protein level, ERα target genes expression and estrogen response element activity in breast cancer cells, while SHARPIN overexpression could reverse these effects. SHARPIN depletion significantly decreases estrogen stimulated cell proliferation in breast cancer cells, which effect could be further rescued by ERα overexpression. Further mechanistic study reveals that SHARPIN mainly localizes in the cytosol and interacts with ERα both in the cytosol and the nuclear. SHARPIN regulates ERα signaling through protein stability, not through gene expression. SHARPIN stabilizes ERα protein via prohibiting ERα protein poly-ubiquitination. Further study shows that SHARPIN could facilitate the mono-ubiquitinaiton of ERα at K302/303 sites and facilitate ERE luciferase activity. Together, our findings propose a novel ERα modulation mechanism in supporting breast cancer cell growth, in which SHARPIN could be one suitable target for development of novel therapy for ERα positive breast cancer.
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| 2. |
- Li, Ao, et al.
(author)
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Genome architecture and selective signals compensatorily shape plastic response to a new environment
- 2023
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In: The Innovation. - 2666-6758. ; 4:4
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Journal article (peer-reviewed)abstract
- Transcriptional plasticity interacts with natural selection in complex ways and is crucial for the survival of species under rapid climate change. How 3D genome architecture affects transcriptional plasticity and its interaction with genetic adaptation are unclear. We transplanted estuarine oysters to a new environment and found that genes located in active chromatin regions exhibited greater transcriptional plasticity, and changes in these regions were negatively correlated with selective signals. This indicates a trade-off be- tween 3D active regions and selective signals in shaping plastic responses to a new environment. Specifically, a mutation, lincRNA, and changes in the accessibility of a distal enhancer potentially affect its interaction with the ManIIa gene, which regulates the muscle function and survival of oysters. Our findings reveal that 3D genome architecture compensates for the role of genetic adaptation in environmental response to new environments and provide insights into synergetic genetic and epigenetic interactions critical for fitness-related trait and survival in a model marine species.
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| 3. |
- Corcoran, William, 1983, et al.
(author)
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All-optical signal processing using slow light enhanced nonlinearities in silicon waveguides
- 2011
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In: 2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference, CLEO EUROPE/EQEC 2011; Munich; 22 May 2011 through 26 May 2011. - 9781457705335
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Conference paper (peer-reviewed)abstract
- Nonlinear optical processes utilizing the ultrafast Kerr (ξ (3) ) nonlinearity provide a tool to manipulate short, picosecond long optical pulses [1], of interest for high baud rate serial communications. Increasing the nonlinear response of waveguides allows for more compact and potentially more efficient all-optical devices, with many device demonstrations in high index, highly nonlinear materials, such as silicon [2] . Further enhancing the nonlinear response of waveguides can be achieved by using resonant structures to increase the energy density, however demonstrations of signal processing using these structures have been limited to bandwidths of a few 10s of GHz at most (e.g. [3]). © 2011 IEEE.
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| 4. |
- Lei, Yuxin, et al.
(author)
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Optically Active Telecom Defects in MoTe 2 Fewlayers at Room Temperature
- 2023
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In: Nanomaterials. - 2079-4991. ; 13:9
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Journal article (peer-reviewed)abstract
- The optical and electrical properties of semiconductors are strongly affected by defect states. The defects in molybdenum ditelluride (MoTe (Formula presented.)) show the potential for quantum light emission at optical fiber communication bands. However, the observation of defect-related light emission is still limited to cryogenic temperatures. In this work, we demonstrate the deep defect states in MoTe (Formula presented.) fewlayers produced via a standard van der Waal material transfer method with a heating process, which enables light emission in the telecommunication O-band. The optical measurements show evidence of localized excitons and strong interaction among defects. Furthermore, the optical emission of defects depends on the thickness of the host materials. Our findings offer a new route for tailoring the optical properties of two-dimensional materials in optoelectronic applications.
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| 5. |
- Li, Juntao, et al.
(author)
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Effect of graphene oxide as a filler material on the mechanical properties of LLDPE nanocomposites
- 2019
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In: Journal of composite materials. - : Sage Publications. - 0021-9983 .- 1530-793X. ; 53:19, s. 2761-2773
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Journal article (peer-reviewed)abstract
- Graphene oxide (GO) has high aspect ratios than many nanosize fillers such as carbon nanotubes and clay, besides its better mechanical properties than many polymers; so they are preferred as a filler material in polymer matrix composites. In this study, the effect of GO on the mechanical properties of linear low-density polyethylene (LLDPE) were experimentally investigated. LLDPE-GO nanocomposites were prepared by melt compounding method, and the extruded nanocomposite was shaped by injection molding machine for the mechanical tests. The mechanical properties investigated included tensile properties, fatigue properties, as well as hardness properties. Differential scanning calorimeter (DSC) was employed to study the thermal characterization of the composites. The results revealed that the addition of GO nanosheets indeed had a positive effect on the tensile, fatigue, and hardness properties. The tensile strength, Young's modulus, and Shore D hardness value were increased by 27.4%, 31.3%, and 9%, respectively, with a GO loading ranging from 0 wt.% to 2 wt.%. The addition of GO had a significant effect on the fatigue properties of the composites such as nearly exponential increment in the cyclic numbers. The samples with 2 wt.% of GO could endure up to 10(6) cycles during the tests, which is 100 times that of pure LLDPE. The morphological analysis via X-ray diffraction (XRD) and transmission electron microscopy (TEM) indicated that GO nanosheets were well exfoliated in the LLDPE matrix. However, there is no significant effect on the melting temperature, crystallization temperature and crystallinity of LLDPE based on DSC result.
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| 6. |
- Lin, Qiaoling, et al.
(author)
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Interlayer Exciton Lasing in Atomically Thin Heterostructures
- 2023
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In: International Conference on Metamaterials, Photonic Crystals and Plasmonics. - 2429-1390. ; , s. 1691-
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Conference paper (peer-reviewed)abstract
- We present an interlayer exciton laser composed of a MoS2/WSe2 heterostructure integrated with a silicon photonic topological microcavity with a quality factor of up to 104. We achieve excitonic lasing with ultra-low threshold, high side-mode suppression ratio and the longest emission wavelength to the telecommunication O-band.
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| 7. |
- Tsuneto, Makoto, et al.
(author)
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Anomalous thermal effect in ZrTe5 observed via photothermal measurements
- 2024
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In: Physical Review Applied. - : American Physical Society (APS). - 2331-7019. ; 21:3
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Journal article (peer-reviewed)abstract
- In this study, we explore the magnetothermoelectric power (MTP) of ZrTe5, a canonical Dirac semimetal, through a photothermal technique. Unlike conventional thermoelectric studies that rely on on-chip heaters and are limited by fabrication processes, especially for stress-sensitive materials, our approach utilizes photothermal effects to induce temperature gradients. Our experiments, applying a magnetic field approximately parallel and transverse to the photocurrent detection direction, reveal that the photothermal method efficiently and reliably extracts both diagonal and off-diagonal components of the thermoelectric coefficient of ZrTe5. We observe that the longitudinal MTP reproduces features previously reported in thermal transport studies, while the photoinduced transverse MTP confirms the anomalous Nernst effect. This photothermal measurement technique opens avenues for investigating transport properties in a wide range of quantum materials, in both three-dimensional and two-dimensional systems.
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