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- Kristanl, Matej, et al.
(author)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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In: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Conference paper (peer-reviewed)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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- Hu, Jinhong, et al.
(author)
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Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults
- 2008
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In: PLOS ONE. - : PLOS. - 1932-6203. ; 3:4
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Journal article (peer-reviewed)abstract
- BACKGROUND: The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation study to evaluate the safety and immunogenicity of the PfCP-2.9 formulated with a novel adjuvant Montanide ISA720. Fifty-two subjects were randomly assigned to 4 dose groups of 10 participants, each receiving the test vaccine of 20, 50, 100, or 200 microg respectively, and 1 placebo group of 12 participants receiving the adjuvant only.METHODS AND FINDINGS: The vaccine formulation was shown to be safe and well-tolerated, and none of the participants withdrew. The total incidence of local adverse events (AEs) was 75%, distributed among 58% of the placebo group and 80% of those vaccinated. Among the vaccinated, 65% had events that were mild and 15% experienced moderate AEs. Almost all systemic adverse reactions observed in this study were graded as mild and required no therapy. The participants receiving the test vaccine developed detectable antibody responses which were boosted by the repeated vaccinations. Sixty percent of the vaccinated participants had high ELISA titers (>1:10,000) of antigen-specific antibodies which could also recognize native parasite proteins in an immunofluorescence assay (IFA).CONCLUSION: This study is the first clinical trial for this candidate and builds on previous investigations supporting PfCP-2.9/ISA720 as a promising blood-stage malaria vaccine. Results demonstrate safety, tolerability (particularly at the lower doses tested) and immunogenicity of the formulation. Further clinical development is ongoing to explore optimizing the dose and schedule of the formulation to decrease reactogenicity without compromising immunogenicity.TRIAL REGISTRATION: Chinese State Food and Drug Administration (SFDA) 2002SL0046; Controlled-Trials.com ISRCTN66850051 [66850051].
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| 5. |
- Wang, Yuhang, et al.
(author)
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Purification and characterization of recombinant human bile salt-stimulated lipase expressed in milk of transgenic cloned cows
- 2017
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In: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:5
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Journal article (peer-reviewed)abstract
- Bile salt-stimulated lipase (BSSL) is a lipolytic digestive enzyme with broad substrate specificity secreted from exocrine pancreas into the intestinal lumen in all species and from the lactating mammary gland into the milk of some species, notably humans but not cows. BSSL in breast milk facilitates digestion and absorption of milk fat and promotes growth of small for gestational age preterm infants. Thus, purified recombinant human BSSL (rhBSSL) can be used for treatment of patients with fat malabsorption and expressing rhBSSL in the milk of transgenic cloned cows would therefore be a mean to meet a medical need. In the present study, a vector pBAC-hLF-hBSSL was constructed, which efficiently expressed active rhBSSL in milk of transgenic cloned cows to a concentration of 9.8 mg/ml. The rhBSSL purified from cow milk had the same enzymatic activity, N-terminal amino acid sequence, amino acid composition and isoelectric point and similar physicochemical characteristics as human native BSSL. Our study supports the use of transgenic cattle for the cost-competitive, large-scale production of therapeutic rhBSSL.
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| 6. |
- Li, Duan, et al.
(author)
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Sinterability of the oxynitride LaTiO2N with perovskite-type structure
- 2014
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In: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 586, s. 567-573
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Journal article (peer-reviewed)abstract
- Based on a thermal stability study, the sinterability of the oxynitride LaTiO2N was investigated by spark plasma sintering (SPS). The results show that LaTiO2N is thermodynamically unstable above ca. 400 degrees C in air and ca. 800 degrees C in argon. While it appears impossible to completely avoid decomposition during sintering, LaTiO2N ceramics with relative density of 74-94% and a residual LaTiO2N content of 57-90 wt% were prepared. By manipulating kinetics, a relative density of 94% was achieved at 1350 degrees C under an uniaxially applied pressure of 125 MPa. This density is higher than any other counterparts prepared by conventional sintering so far. SPS appears a feasible tool for manipulating the sintering kinetics. It enables the preparation of almost dense LaTiO2N bulks with adequate purity.
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| 7. |
- Li, Wenjie, et al.
(author)
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A study on the thermal conversion of scheelite-type ABO(4) into perovskite-type AB(O,N)(3)
- 2015
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In: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; 44:17, s. 8238-8246
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Journal article (peer-reviewed)abstract
- Phase-pure scheelite AMoO(4) and AWO(4) (A = Ba, Sr, Ca) were thermally treated under an ammonia atmosphere at 400 to 900 degrees C. SrMoO4 and SrWO4 were shown to convert into cubic perovskite SrMoO2N and SrWO1.5N1.5, at 700 degrees C and 900 degrees C respectively, and to form metastable intermediate phases (scheelite SrMoO4-xNx and SrWO4-xNx), as revealed by X-ray diffraction (XRD), elemental analysis and FTIR spectroscopy. High-temperature oxide melt solution calorimetry reveals that the enthalpy of formation for SrM(O,N)(3) (M = Mo, W) perovskites is less negative than that of the corresponding scheelite oxides, though the conversion of the scheelite oxides into perovskite oxynitrides is thermodynamically favorable at moderate temperatures. The reaction of BaMO4 with ammonia leads to the formation of rhombohedral Ba3M2(O,N)(8) and the corresponding binary metal nitrides Mo3N2 and W4.6N4; similar behavior was observed for CaMO4, which converted upon ammonolysis into individual oxides and nitrides. Thus, BaMO4 and CaMO4 were shown to not provide access to perovskite oxynitrides. The influence of the starting scheelite oxide precursor, the structure distortion and the degree of covalency of the B-site-N bond are discussed within the context of the formability of perovskite oxynitrides.
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| 8. |
- Li, Wenjie, et al.
(author)
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Synthesis and rapid sintering of dense SrA(O,N)(3) (A = Mo, W) oxynitride ceramics
- 2015
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In: Journal of the European Ceramic Society. - : Elsevier BV. - 0955-2219 .- 1873-619X. ; 35:12, s. 3273-3281
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Journal article (peer-reviewed)abstract
- SrMo(O,N)(3) and SrW(O,N)(3) oxynitride powders were synthesized via a solvothermal route followed by ammonolysis. Their rapid densification by spark plasma sintering with a heating rate of 300-400 degrees C/min under a uniaxial pressure of 100 MPa yielded dense monoliths. The lowest open porosity achieved was 0 vol% for SrMo(O,N)(3) and 7.6 vol% for SrW(O,N)(3). The compacted monoliths were characterized by elemental analysis, electron microscopy (SEM, TEM) coupled with energy dispersive X-ray spectroscopy (EDX), as well as X-ray diffraction (XRD). Rietveld refinement of the XRD patterns revealed in the case of the compacted SrMo(O,N)(3) the formation of small amount of ternary oxides (Sr3Mo2O7/SrMoO4/Sr3MoO6), molybdenum nitride (MO2N), as well as metallic Mo. On the contrary, SrW(O,N)(3) exhibited significant decomposition after consolidation, with SrWO4/Sr3WO6 being main components beside SrMo(O,N)(3), accompanied by tungsten nitride (WN) and metallic W. Thus, rapid SPS enables the densification of oxynitrides with high density and acceptable purity that were hardly achieved earlier.
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| 9. |
- Li, Xiangyu, et al.
(author)
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Two-phase flow patterns identification in porous media using feature extraction and SVM
- 2022
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In: International Journal of Multiphase Flow. - : Elsevier BV. - 0301-9322 .- 1879-3533. ; 156
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Journal article (peer-reviewed)abstract
- Rapid and accurate identification of two-phase flow patterns in porous media is of great significance to the chemical industry, petroleum and nuclear engineering, etc. Based on the different pressure signals of gas-liquid two-phase flow in a porous bed, the present work proposes an intelligent recognition method to identify the two-phase flow patterns in porous media by the technologies of feature extraction and support vector machine (SVM). The analysis techniques, including time domain (PDF), frequency domain (PSD) and time-frequency domain (Wavelet), are employed to extract and summarize the corresponding characteristics of differential pressure signals of flow patterns. The intelligent recognition models are developed to identify the two-phase flow patterns in porous media by SVM. The models are trained respectively based on the characteristics of time domain + frequency domain (TF-SVM model), time domain + wavelet (TW-SVM model) and frequency domain + wavelet (FW-SVM model). The overall identification accuracy of the optimal model (TW-SVM model) reaches 96.08%.
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| 10. |
- Miao, Yanfeng, et al.
(author)
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Stable and bright formamidinium-based perovskite light-emitting diodes with high energy conversion efficiency
- 2019
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Journal article (peer-reviewed)abstract
- Solution-processable perovskites show highly emissive and good charge transport, making them attractive for low-cost light-emitting diodes (LEDs) with high energy conversion efficiencies. Despite recent advances in device efficiency, the stability of perovskite LEDs is still a major obstacle. Here, we demonstrate stable and bright perovskite LEDs with high energy conversion efficiencies by optimizing formamidinium lead iodide films. Our LEDs show an energy conversion efficiency of 10.7%, and an external quantum efficiency of 14.2% without outcoupling enhancement through controlling the concentration of the precursor solutions. The device shows low efficiency droop, i.e. 8.3% energy conversion efficiency and 14.0% external quantum efficiency at a current density of 300 mA cm(-2), making the device more efficient than state-of-the-art organic and quantum-dot LEDs at high current densities. Furthermore, the half-lifetime of device with benzylamine treatment is 23.7 hr under a current density of 100 mA cm(-2), comparable to the lifetime of near-infrared organic LEDs.
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