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- Caidahl, Kenneth, 1949, et al.
(author)
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New concept in echocardiography: harmonic imaging of tissue without use of contrast agent.
- 1998
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In: Lancet (London, England). - : Elsevier BV. - 0140-6736. ; 352:9136, s. 1264-70
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Journal article (peer-reviewed)abstract
- Endocardial border detection is important for echocardiographic assessment of left-ventricular function. Second harmonic imaging of contrast agents enhances this border detection. We discovered that harmonic imaging improves tissue visualisation even before contrast injection. We therefore sought objectively to demonstrate the degree of enhancement of endocardial and myocardial visualisation.An ATL HDI-3000 scanner with software for contrast harmonic imaging was used to record short-axis images of the left ventricle in 27 patients with possible myocardial disease and 22 controls, in the fundamental mode and with harmonic imaging. A computer program measured the relative grey-scale values within six segments of the endocardium and myocardium. An Acuson Sequoia scanner equipped with software for tissue harmonic imaging was used to investigate the reproducibility of ejection-fraction calculations in 22 patients with ischaemic heart disease.Harmonic imaging produced brighter endocardium within each segment. Relative to the mean grey value of the total imaging sector, the values for harmonic and fundamental imaging were 171.5 vs 85.6% (p<0.0001) in end diastole and 194.1 vs 106.7% (p<0.0001) in end systole. Results for the myocardial segments were also significantly better for harmonic imaging. Structure enhancement of similar magnitude was seen among patients and healthy controls. Use of harmonic imaging reduced the proportion of unacceptable images by 14-46% in different views and improved the reproducibility of biplane ejection-fraction measurements.In comparison with fundamental imaging, the relative endocardial and myocardial brightness is enhanced by harmonic imaging.
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- Aminoff, A, et al.
(author)
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Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.
- 2010
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In: Journal of lipid research. - 0022-2275 .- 1539-7262. ; 51:1, s. 103-11
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Journal article (peer-reviewed)abstract
- Promoter polymorphisms in microsomal triglyceride transfer protein (MTTP) have been associated with decreased plasma lipids but an increased risk for ischemic heart disease (IHD), indicating that MTTP influences the susceptibility for IHD independent of plasma lipids. The objective of this study was to characterize the functional promoter polymorphism in MTTP predisposing to IHD and its underlying mechanism. Use of pyrosequencing technology revealed that presence of the minor alleles of the promoter polymorphisms -493G>T and -164T>C result in lower transcription of MTTP in vivo in the heart, liver, and macrophages. In vitro experiments indicated that the minor -164C allele mediates the lower gene expression and that C/EBP binds to the polymorphic region in an allele-specific manner. Furthermore, homozygous carriers of the -164C were found to have increased risk for IHD as shown in a case-control study including a total of 544 IHD patients and 544 healthy control subjects. We concluded that carriers of the minor -164C allele have lower expression of MTTP in the heart, mediated at least partly by the transcription factor CCAAT/enhancer binding protein, and that reduced concentration of MTTP in the myocardium may contribute to IHD upon ischemic damage.
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- Hugelius, Karin, 1977-, et al.
(author)
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Vital and Clinical Signs Gathered Within the First Minutes After a Motorcycle Accident on a Racetrack: an Observational Study
- 2021
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In: Sports Medicine-Open. - : Springer Science and Business Media LLC. - 2199-1170 .- 2198-9761 .- 0112-1642 .- 1179-2035. ; 7:1
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Journal article (peer-reviewed)abstract
- Background Little is known about vital signs during the very first minutes after an accident. This study aimed to describe the vital signs of motorcycle riders shortly after racetrack crashes and examine the clinical value of these data for the prehospital clinical assessments. Methods A retrospective observational cohort based on data from medical records on 104 motorcycle accidents at a racetrack in Sweden, covering the season of 2019 (May 01 until September 17), was conducted. Both race and practice runs were included. In addition, data from the Swedish Trauma Registry were used for patients referred to the hospital. Kruskal-Wallis test and linear regression were calculated in addition to descriptive statistics. Results In all, 30 riders (29%) were considered injured. Sixteen riders (15%) were referred to the hospital, and of these, five patients (5% of all riders) had suffered serious injuries. Aside from a decreased level of consciousness, no single vital sign or kinematic component observed within the early minutes after a crash was a strong clinical indicator of the occurrence of injuries. However, weak links were found between highsider or collision crashes and the occurrence of injuries. Conclusion Except for a decreased level of consciousness, this study indicates that the clinical value of early measured vital signs might be limited for the pre-hospital clinical assessment in the motorsport environment. Also, an adjustment of general trauma triage protocols might be considered for settings such as racetracks. Using the context with medical professionals at the victim's side within a few minutes after an accident, that is common in motorsport, offers unique possibilities to increase our understanding of clinical signs and trauma in the early state after an accident.
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- Jacobson, Bengt J H, 1962, et al.
(author)
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Potential effectiveness of a stability control system for passenger cars after an initial side impact
- 2014
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In: FISITA 2014 World Automotive Congress - Proceedings.
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Conference paper (peer-reviewed)abstract
- Vehicle multiple-event accidents constitute 1/4-1/3 of all severe accidents. The present paper studies the control of the vehicle’s abnormal motion after being hit by another vehicle. The potential effectiveness of such a stability control system is estimated through accident data analysis and vehicle dynamics simulation. Only side impacts were simulated, but engineering judgments were made to project the effectiveness potential prediction on the total traffic work. Assuming ESC-like control (closed loop control on yaw rate, using wheel brakes) it is found that the function has potential to mitigate accident for up to 10-9 cars per driven km, or up to 0.1% of the cars in the accident database. While assuming Post Impact Stability Control by steering (closed loop control on yaw angle and path deviation, using steering), the corresponding figures are approximately ten times higher.
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- Lidberg, Martin, 1964, et al.
(author)
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An improved and extended GPS-derived 3D velocity field of the glacial isostatic
- 2007
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In: Journal of Geodesy. - : Springer Science and Business Media LLC. - 0949-7714 .- 1432-1394. ; 81:3, s. 213-230
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Journal article (peer-reviewed)abstract
- We present a new GPS-derived 3D velocity field for the Fennoscandia glacial isostatic adjustment (GIA) area. This new solution is based upon 3,000 days of continuous GPS observations obtained from the permanent networks in Fennoscandia. The period encompasses a prolongated phase of stable observation conditions after the northern autumn of 1996. Several significant improvements have led to smaller uncertainties and lower systematic errors in the new solutions compared to our previous results. The GPS satellite elevation cut-off angle was lowered to 10°, we fixed ambiguities to integers where possible, and only a few hardware changes occurred over the entire network. The GAMIT/GLOBK software package was used for the GPS analysis and reference frame realization. Our new results confirmed earlier findings of maximum discrepancies between GIA models and observations in northern Finland. The reason may be related to overestimated ice-sheet thickness and glaciation period in the north. In general, the new solutions are more coherent in the velocity field, as some of the perturbations are now avoided. We compared GPS-derived GIA rates with sea-level rates from tide-gauge observations, repeated precise leveling, and with GIA model computations, which showed consistency. © Springer-Verlag 2006.
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