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- Fugmann, Andreas, et al.
(author)
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Blood flow is an important determinant of forearm glucose uptake following a mixed meal
- 2003
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In: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 40:3, s. 113-117
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Journal article (peer-reviewed)abstract
- Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p<0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p<0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p<0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p<0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p<0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.
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| 3. |
- Sarabi, Mahziar, et al.
(author)
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An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects
- 2001
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In: Acta Physiologica Scandinavica. - 0001-6772 .- 1365-201X. ; 172:2, s. 107-113
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Journal article (peer-reviewed)abstract
- This study was designed to evaluate the effects of an ordinary mixed meal on endothelium-dependent vasodilation. Ten young healthy volunteers were given a mixed meal (minced meat sauce with rice, 900 kcal, 34% of the energy content was fat). In the fasting state, at 60 and 120 min after the start of the meal, endothelium-dependent vasodilation and endothelium-independent vasodilation were evaluated by local infusion of metacholine (4 microg min (-1)) and sodium nitroprusside (10 microg min (-1)) in the brachial artery. Blood flow in the forearm was measured using venous occlusion plethysmography. Endothelium-dependent vasodilation decreased from 15.4 +/- 3.3 (mean +/- SD) at fasting to 13.7 +/- 3.5 mL min (-1) (100 mL tissue)-1 (P < 0.01) 60 min after feeding, but had returned to the fasting level at 120 min. At 60 min, but not in the fasting state, the serum level of free fatty acids was inversely related to endothelium-dependent vasodilation (r=-0.74, P < 0.05), although no significant net changes in FFA levels were seen. Endothelium-independent vasodilation was not affected by the mixed meal. No similar attenuations in endothelium-dependent vasodilation were seen during control meals. In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function.
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| 5. |
- Steer, Peter, et al.
(author)
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The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans
- 2003
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In: Clinical Science. - 0143-5221 .- 1470-8736. ; 105:1, s. 81-87
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Journal article (peer-reviewed)abstract
- Impaired endothelium-dependent vasodilation (EDV) is an early marker of atherosclerosis. The aim of the present study was to investigate how meals with different fat contents influence endothelial vasodilatory function. A total of 26 young, healthy men and women aged 20-30 years ingested an ordinary Western meal [34 energy% (E%) fat, n =10], or isocaloric meals with low-fat (20 E%, n =8), or minimal-fat (3 E%, n =8) content. EDV was assessed as forearm blood flow (FBF) during local administration of 4 microg/min methacholine chloride (Mch-FBF) and endothelium-independent vasodilation as FBF during administration of 10 microg/min sodium nitroprusside (SNP-FBF) at baseline and 1 and 2 h after each meal. FBF was determined by venous occlusion plethysmography. An endothelial function index (EFI) was calculated as the Mch-FBF/SNP-FBF ratio. Both Mch-FBF and the EFI were decreased at 1 h after the 34 E% fat meal ( P <0.01 and P <0.05 respectively), but approached fasting levels after 2 h. Mch-FBF and EFI did not change significantly in the group consuming the 20 E% fat meal, but increased in the 3 E% fat group ( P <0.01 and P <0.05 compared with baseline for Mch-FBF and EFI respectively). SNP-FBF was not significantly affected by any of the meals. In conclusion, low-fat meals did not attenuate EDV, in contrast with an ordinary Western meal, which transiently impaired EDV. Our findings indicate that a dietary fat content of 20 E% or less might be beneficial to endothelial vasodilatory function.
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| 6. |
- Åkesson, Agneta, et al.
(author)
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Metaller i miljön - riskfaktorer under graviditet och amning
- 1999
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Reports (other academic/artistic)abstract
- SammanfattningVid studier av metallkoncentrationer i blod hos gravida är det viktigt att beakta denfysiologiska utspädning av blodkropparna som sker och är som mest uttalad i början av tredjetrimestern.Belastningen av kadmium förefaller öka efter genomgången graviditet, vilket till stor del kanförklaras av en ökad absorption av kadmium i tarmen på grund av samtidigt ökadjärnabsorption. Hos kvinnor som sammantaget fött flera barn var ökning av urinkadmiummed stigande ålder mer uttalad än för de kvinnor som fött inget eller ett barn.Metylkvicksilver utgjorde 75% av den gravida kvinnans totalkvicksilver i blod och vardessutom nästan dubbelt så hög i navelsträngsblod som i moderns före förlossning. Halten avmetylkvicksilver i navelsträngsblod var relaterat till moderns fiskintag medan halten avoorgansikt kvicksilver hos barnet var relaterat till antalet amalgamfyllningar hos modern.Halten oorganiskt kvicksilver i blod sjönk under och efter amningsperioden vilket kanförklaras av en utsöndring till modersmjölken.Koncentrationen av bly i navelsträngsblod var lika hög som hos modern fyra veckor föreförlossning. Blodblyhalten hos modern efter genomgången graviditet föreföll öka vilketkanske kan förklaras av en högre benomsättning under amningsperioden än undergraviditeten, och därmed en frisättning av bly från benvävnad. Detta kommer senare attutvärderas i förhållande till markörer för benomsättning.
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