| 1. |
- Aronsson, Martin, et al.
(author)
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ACOOR Rapport 1; Tuff: Systemöversikt och arkitektur
- 2000. - 1
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Reports (other academic/artistic)abstract
- TUFF är ett verktyg för strategisk planering av tågrörelser och resursomlopp (f.n. lok). Det unika med TUFF är inte att kunna utföra dessa planeringar var för sig, utan att de kan samverka. Detta är möjligt dels genom att de ingående komponenterna kan hantera vagare data, t.ex. tidsintervall i stället för fasta tider vilket är det vanliga annars bland kommersiella lösningar, dels att det finns en samordningsfunktion, som vi kallar samordningsagent, som samordnar olika planer från olika planeringsfunktioner. Denna samordnare är programmerbar via ett speciellt språk, så att ett stort problem kan splittras upp i mindre delar, och resultat från olika planeringar av dessa delar kan sedan kombineras och nya resultat genereras. Tanken med denna integrering av olika planeringsfunktioner är att åstadkomma globalt bättre lösningar, jämfört med när varje problem löses var för sig, genom att ta hänsyn till varje planeringsproblems krav tidigt i planeringscykeln.
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| 2. |
- Betsholtz, Christer, 1959, et al.
(author)
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Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.
- 2004
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In: Current opinion in nephrology and hypertension. - 1062-4821. ; 13:1, s. 45-52
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Journal article (peer-reviewed)abstract
- PURPOSE OF REVIEW: The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells. RECENT FINDINGS: The lethality of these mutants has precluded analysis of the physiological and pathophysiological consequences of platelet-derived growth factor-B and platelet-derived growth factor beta-receptor deficiency in adults. This review summarizes and discusses recent data from certain tissue-specific and subtle mutations in the platelet-derived growth factor-B and platelet-derived growth factor beta-receptor genes that are compatible with postnatal viability in spite of severe developmental deficits in pericyte and mesangial cell recruitment. In the postnatal period, the animals studied developed a characteristic set of pathological changes to small blood vessels of the retina and the kidney glomerulus, which sheds light on the importance of pericytes and mesangial cells for vascular integrity and function after birth. SUMMARY: These microvascular abnormalities and their consequences bear a resemblance to diabetic microangiopathy and nephropathy. The platelet-derived growth factor-B and platelet-derived growth factor beta-receptor mutant mouse models, therefore, might serve as valuable tools in the dissection of some of the pathogenic events in diabetic microangiopathy.
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| 3. |
- Lindblom, Per, 1974, et al.
(author)
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Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
- 2003
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In: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 17:15, s. 1835-40
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Journal article (peer-reviewed)abstract
- Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
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| 4. |
- Lindblom, Per, et al.
(author)
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Learning orthopaedics : assessing medical students' experiences of interprofessional training in an orthopaedic clinical education ward.
- 2007
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In: J Interprof Care. - : Informa UK Limited. - 1356-1820 .- 1469-9567. ; 21:4, s. 413-23
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Journal article (other academic/artistic)abstract
- Interprofessional training is becoming commonplace in undergraduate medical education. Orthopaedics is considered to be a setting that offers good opportunities for interprofessional training. Curriculum overload is a common problem, which has to be addressed with respect to content. The aim of this study was to assess medical students' experiences of interprofessional care during their orthopaedic training. Over a two-week period, medical, nursing, physiotherapy and occupational therapy students trained together in teams in an orthopaedic ward (Clinical Education Ward, CEW). A questionnaire was distributed to assess the impact of this new curriculum on medical students. A patient-satisfaction questionnaire was also administered to assess patients' satisfaction with the treatment provided by students at the CEW. In general, the medical students were satisfied with the interprofessional course in the CEW. Of the 178 medical students who took the course, 134 (75%) responded to the questionnaire. Total time devoted to orthopaedics was reported to be between 7 - 44% (mean). The total time regarding medical tasks was reported to be between 57 - 71% (mean). Results from the patient-satisfaction questionnaire showed that patients perceived CEW as highly satisfactory. The medical students reported generally satisfactory experiences of interprofessional orthopaedic training in general. In an interprofessional training context, professional supervision and role modeling takes on added importance, and may be regarded as essential ingredients in helping students to learn effectively within an authentic clinical setting.
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| 5. |
- Lindblom, Simon, et al.
(author)
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ACOOR Rapport 2: Översikt av tekniker och metoder
- 2000. - 1
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Reports (other academic/artistic)abstract
- I arbetet med att modellera ett produktionsplaneringsproblem i järnvägsindustrin har vi identifierat ett antal metoder och tekniker som vi hävdar är användbara även utanför järnvägsdomänen. I denna rapport presenterar vi kort problemställningarna i järnvägsdomänen, presenterar de viktigaste av de tekniker vi identifierat, använt och utvecklat samt indikerar en del andra problemdomäner för vilka vi bedömer att dessa tekniker skulle kunna användas.
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| 6. |
- Salvén, Håkan, et al.
(author)
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”Gymnasieelever bör studera filosofi”
- 2023
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In: Svenska dagbladet. - 1101-2412. ; :2023-04-16
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Journal article (pop. science, debate, etc.)abstract
- Filosofin har en särställning när det handlar om att stärka elevernas skydd mot desinformation och att utveckla deras kritiska tänkande. Därför bör ämnet vara obligatoriskt för elever på de teoretiska programmen i Gymnasiet.
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| 7. |
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| 8. |
- Abramsson, Alexandra, 1973, et al.
(author)
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Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
- 2007
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In: GENES & DEVELOPMENT. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 21:3, s. 316-331
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Journal article (peer-reviewed)abstract
- During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during vascular development. We studied the participation of HS chains in pericyte recruitment using two mouse models with altered HS biosynthesis. Reduction of N-sulfation due to deficiency in N-deacetylase/N-sulfotransferase-1 attenuated PDGF-BB binding in vitro, and led to pericyte detachment and delayed pericyte migration in vivo. Reduced N-sulfation also impaired PDGF-BB signaling and directed cell migration, but not proliferation. In contrast, HS from glucuronyl C5-epimerase mutants, which is extensively N- and 6-O-sulfated, but lacks 2-O-sulfated L-iduronic acid residues, retained PDGF-BB in vitro, and pericyte recruitment in vivo was only transiently delayed. These observations were supported by in vitro characterization of the structural features in HS important for PDGF-BB binding. We conclude that pericyte recruitment requires HS with sufficiently extended and appropriately spaced N-sulfated domains to retain PDGF-BB and activate PDGF receptor β (PDGFRβ) signaling, whereas the detailed sequence of monosaccharide and sulfate residues does not appear to be important for this interaction.
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| 9. |
- Ahearn, Thomas U., et al.
(author)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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In: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Journal article (peer-reviewed)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 10. |
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Anarkosyndikalismens återkomst i Spanien : SACs samarbete med CNT under övergången från diktatur till demokrati
- 2014. - 1
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Editorial collection (other academic/artistic)abstract
- Ett av de mest spektakulära inslagen i den spanska demokratiseringsprocess, som inleddes i samband med Francos död 1975, var den anarkosyndikalistiska fackföreningsrörelsen CNTs återkomst i legaliteten. Efter närmare 40 år av diktatur betraktades CNT av många som uträknat. Att hundratusentals människor samlades i rörelsens gamla högborg Barcelona för att bevista CNTs återkomst kom därför som en chock för det spanska etablissemanget. Det föreföll nu som att CNT var på väg att återta sin forna roll som en av de stora drivande krafterna i det spanska samhället.En av orsakerna till att det svenska SAC kom att spela en liten men inte obetydlig roll i denna process var att SAC under denna tid var CNTs viktigaste internationella samarbetspartner. Att SAC, till skillnad från CNT, aldrig varit olagligförklarat hade inneburit att SAC haft möjlighet att bygga upp ekonomiska resurser med vilka man alltsedan 1930-talet kunnat ge ett välbehövligt stöd till CNT.Här publiceras en utskrift från ett vittnesseminarium där tre av SACs tidigare internationella sekreterare berättar om sina erfarenheter från denna dramatiska tid. Seminariet behandlade SACs relationer med CNT men kom också att handla om fackföreningsrörelsen, exilrörelser, demokratiseringsprocesser och inte minst om den politiska och sociala situationen i Spanien från inbördeskriget och fram till idag.
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