| 1. |
- Uhlén, Mathias, et al.
(author)
-
A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
-
In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
-
Journal article (peer-reviewed)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
|
|
| 2. |
- Astor, Kim, et al.
(author)
-
Maternal postpartum depression impacts infants' joint attention differentially across cultures
- 2022
-
In: Developmental Psychology. - : American Psychological Association (APA). - 0012-1649 .- 1939-0599. ; 58:12, s. 2230-2238
-
Journal article (peer-reviewed)abstract
- We assessed whether the negative association between maternal postpartum depression (PPD) and infants’ development of joint attention (gaze following) generalizes from WEIRD (Western, Educated, Industrialized, Rich, and Democratic) to Majority World contexts. The study was conducted in Bhutan (N = 105, M = 278 days, 52% males) but also draws from publicly available Swedish data (N = 113, M = 302 days, 49% males). We demonstrate that Bhutanese and Swedish infants’ development follows the same trajectory. However, Bhutanese infants’ gaze following were not related to maternal PPD, which the Swedish infants’ were. The results support the notion that there are protecting factors built into the interdependent family model. Despite all the benefits of being raised in a modern welfare state, it seems like Swedish infants, to an extent, are more vulnerable to maternal mental health than Bhutanese infants.
|
|
| 3. |
- Astor, Kim, et al.
(author)
-
Social and emotional contexts predict the development of gaze following in early infancy
- 2020
-
In: Royal Society Open Science. - : The Royal Society. - 2054-5703. ; 7:9
-
Journal article (peer-reviewed)abstract
- The development of gaze following begins in early infancy and its developmental foundation has been under heavy debate. Using a longitudinal design (N = 118), we demonstrate that attachment quality predicts individual differences in the onset of gaze following, at six months of age, and that maternal postpartum depression predicts later gaze following, at 10 months. In addition, we report longitudinal stability in gaze following from 6 to 10 months. A full path model (using attachment, maternal depression and gaze following at six months) accounted for 21% of variance in gaze following at 10 months. These results suggest an experience-dependent development of gaze following, driven by the infant's own motivation to interact and engage with others (the social-first perspective).
|
|
| 4. |
- Bergh, Robin, 1983-, et al.
(author)
-
The group-motivated sampler
- 2019
-
In: Journal of experimental psychology. General. - : American Psychological Association. - 0096-3445 .- 1939-2222. ; 148:5, s. 845-862
-
Journal article (peer-reviewed)abstract
- Does ingroup favoritism reflect experience or some preset motivation? The latter possibility is well examined in social psychology, but models from cognitive psychology suggest that unrepresentative samples of experience can generate biases even in the absence of motivational concerns. It remains unclear, however, how motivation and initially sampled experiences interact when both influences are possible, and people encounter new groups. Extending classic arguments about motivated information gathering, we propose that people can be described as “group-motivated samplers”—marked by a tendency to primarily seek out information about one’s own group, and to attend more to information that portrays the ingroup in a positive light. Four experiments showed that information seeking almost always starts with the ingroup, and that people chose to gather more information from the ingroup compared to an outgroup. In subsequent group evaluations, people were excessively positive about ingroups giving a good initial impression. Participants were also fairly accurate, on average, about the direction and magnitude of group differences when the ingroup was de facto better, but downplayed those differences in the opposite situation. Further analyses indicated that first experiences led to biased evaluations because people failed to discount for nonrepresentative (positive) ingroup experiences, whereas interpretive biases seem responsible for evaluations based on belonging to a better/worse performing group. Taken together, while social psychologists know that people tend to portray ingroups in a flattering light, we show how people selectively incorporate early experiences to build those impressions.
|
|
| 5. |
- Eriksson, Kimmo, 1967-, et al.
(author)
-
Encoding of Numerical Information in Memory : Magnitude or Nominal?
- 2017
-
In: Journal of Numerical Cognition. - : The Mathematical Cognition and Learning Society. - 2363-8761. ; 3:1, s. 58-76
-
Journal article (peer-reviewed)abstract
- In studies of long-term memory of multi-digit numbers the leading digit tends to be recalled correctly more often than less significant digits, which has been interpreted as evidence for an analog magnitude encoding of the numbers. However, upon closer examination of data from one of these studies we found that the distribution of recall errors does not fit a model based on analog encoding. Rather, the data suggested an alternative hypothesis that each digit of a number is encoded separately in long-term memory, and that encoding of one or more digits sometimes fails due to insufficient attention in which case they are simply guessed when recall is requested, with no regard for the presented value. To test this hypothesis of nominal encoding with value-independent mistakes, we conducted two studies with a total of 1,080 adults who were asked to recall a single piece of numerical information that had been presented in a story they had read earlier. The information was a three-digit number, manipulated between subjects with respect to its value (between 193 and 975), format (Arabic digits or words), and what it counted (baseball caps or grains of sand). Results were consistent with our hypothesis. Further, the leading digit was recalled correctly more often than less significant digits when the number was presented in Arabic digits but not when the number was presented in words; our interpretation of this finding is that the latter format does not focus readers’ attention on the leading digit.
|
|
| 6. |
|
|
| 7. |
- Gerbrand, Anton, et al.
(author)
-
Recognition of small numbers in subset knowers : Cardinal knowledge in early childhood
- 2023
-
In: Royal Society Open Science. - : Royal Society. - 2054-5703. ; 10:10
-
Journal article (peer-reviewed)abstract
- Previous research suggests that subset-knowers have an approximate understanding of small numbers. However, it is still unclear exactly what subset- knowers understand about small numbers. To investigate this further, we tested 133 participants, ages 2.6 – 4 years, on a newly developed eye-tracking task targeting cardinal recognition. Participants were presented with two sets differing in cardinality (1–4 items) and asked to find a specific cardinality. Our main finding showed that on a group level, subset- knowers could identify all presented targets at rates above chance, further supporting that subset-knowers understand several of the basic principles of small numbers. Exploratory analyses tentatively suggest that one-knowers could identify the targets 1 and 2, but struggled when the target was 3 and 4, whereas two- knowers and above could identify all targets at rates above chance. This might tentatively suggest that subset-knowers have an approximate understanding of numbers that is just (i.e. +1) above their current knower level. We discuss the implications of these results in length.
|
|
| 8. |
- Gerbrand, Anton, et al.
(author)
-
Statistical learning in infancy predicts vocabulary size in toddlerhood
- 2022
-
In: Infancy. - : John Wiley & Sons. - 1525-0008 .- 1532-7078. ; 27:4, s. 700-719
-
Journal article (peer-reviewed)abstract
- During the first 2 years of life, an infant's vocabulary grows at an impressive rate. In the current study, we investigated the impact of three challenges that infants need to overcome to learn new words and expand the size of their vocabulary. We used longitudinal eye-tracking data (n = 118) to assess sequence learning, associative learning, and probability processing abilities at ages 6, 10, and 18 months. Infants' ability to efficiently solve these tasks was used to predict vocabulary size at age 18 months. We demonstrate that the ability to make audio-visual associations and to predict sequences of visual events predicts vocabulary size in toddlers (accounting for 20% of the variance). Our results indicate that statistical learning in some, but not all, domains have a role in vocabulary development.
|
|
| 9. |
- Gottwald, Janna M., et al.
(author)
-
An Embodied Account of Early Executive-Function Development : Prospective Motor Control in Infancy Is Related to Inhibition and Working Memory
- 2016
-
In: Psychological Science. - : SAGE Publications. - 0956-7976 .- 1467-9280. ; 27:12, s. 1600-1610
-
Journal article (peer-reviewed)abstract
- The importance of executive functioning for later life outcomes, along with its potential to be positively affected by intervention programs, motivates the need to find early markers of executive functioning. In this study, 18-month-olds performed three executive-function tasksinvolving simple inhibition, working memory, and more complex inhibitionand a motion-capture task assessing prospective motor control during reaching. We demonstrated that prospective motor control, as measured by the peak velocity of the first movement unit, is related to infants' performance on simple-inhibition and working memory tasks. The current study provides evidence that motor control and executive functioning are intertwined early in life, which suggests an embodied perspective on executive-functioning development. We argue that executive functions and prospective motor control develop from a common source and a single motive: to control action. This is the first demonstration that low-level movement planning is related to higher-order executive control early in life.
|
|
| 10. |
|
|
