| 1. |
- Egesten, Arne, et al.
(author)
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SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
- 2009
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In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:3
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Journal article (peer-reviewed)abstract
- BACKGROUND: CXC chemokines are induced by inflammatory stimuli in epithelial cells and some, like MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, are antibacterial for Streptococcus pyogenes. METHODOLOGY/PRINCIPAL FINDINGS: SpeB from S. pyogenes degrades a wide range of chemokines (i.e. IP10/CXCL10, I-TAC/CXCL11, PF4/CXCL4, GROalpha/CXCL1, GRObeta/CXCL2, GROgamma/CXCL3, ENA78/CXCL5, GCP-2/CXCL6, NAP-2/CXCL7, SDF-1/CXCL12, BCA-1/CXCL13, BRAK/CXCL14, SRPSOX/CXCL16, MIP-3alpha/CCL20, Lymphotactin/XCL1, and Fractalkine/CX3CL1), has no activity on IL-8/CXCL8 and RANTES/CCL5, partly degrades SRPSOX/CXCL16 and MIP-3alpha/CCL20, and releases a 6 kDa CXCL9 fragment. CXCL10 and CXCL11 loose receptor activating and antibacterial activities, while the CXCL9 fragment does not activate the receptor CXCR3 but retains its antibacterial activity. CONCLUSIONS/SIGNIFICANCE: SpeB destroys most of the signaling and antibacterial properties of chemokines expressed by an inflamed epithelium. The exception is CXCL9 that preserves its antibacterial activity after hydrolysis, emphasizing its role as a major antimicrobial on inflamed epithelium.
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| 2. |
- Grafström, Anna, et al.
(author)
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A Speculative Design Approach to Investigate Interactions for an Assistant Robot Cleaner in Food Plants
- 2022
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In: ACM International Conference Proceeding Series. - New York, NY, USA : ACM.
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Conference paper (peer-reviewed)abstract
- The possibility to support cleaners in a food plant with an assistant robot cleaner is currently being researched. Owing to the interactive nature of a robot with collaborative applications, it is crucial to design interactions that are adapted to allow cleaners to make the best use of these. In this paper, a speculative design approach is used to pursue possible ways to interact with an assisting robot cleaner in a food plant in the future. We report findings from studies that entail observations at three food plants and eleven interviews with cleaners, which then resulted in creating four speculative design concepts. Thereafter, two focus group discussions on the four concepts revealed further insights on future interactions. The final result contains six design recommendations and a future scenario describing user interactions with an assistant robot cleaner in the context of food plants. Finally, we discuss some of our impressions and future work directions.
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| 3. |
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| 4. |
- Jeibmann, Astrid, et al.
(author)
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Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster
- 2014
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 4005-
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Journal article (peer-reviewed)abstract
- Atypical teratoid/rhabdoid tumours (AT/RT) are malignant brain tumours. Unlike most other human brain tumours, AT/RT are characterized by inactivation of one single gene, SMARCB1. SMARCB1 is a member of the evolutionarily conserved SWI/SNF chromatin remodelling complex, which has an important role in the control of cell differentiation and proliferation. Little is known, however, about the pathways involved in the oncogenic effects of SMARCB1 inactivation, which might also represent targets for treatment. Here we report a comprehensive genetic screen in the fruit fly that revealed several genes not yet associated with loss of snr1, the Drosophila homologue of SMARCB1. We confirm the functional role of identified genes (including merlin, kibra and expanded, known to regulate hippo signalling pathway activity) in human rhabdoid tumour cell lines and AT/RT tumour samples. These results demonstrate that fly models can be employed for the identification of clinically relevant pathways in human cancer.
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| 5. |
- Linge, Anna, 1964-
(author)
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Aesthetic learning process within drama, pictures and music
- 2013
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In: The 41st Nordic Educational Research Association (NERA) Conference 2013, (Nordisk Forening For Pedagogisk Forskning (NFPF). - Copenhagen : Nordic Educational Research Association (NERA).
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Conference paper (peer-reviewed)
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| 6. |
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| 7. |
- Linge, Anna, 1964-
(author)
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Begreppet estetiska lärprocesser som musisk-motoriska lärprocesser?
- 2016
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In: Presented at Musikforskning idag, Linnaeus University, Växjö 14-16 june 2016. - Växjö : Linnaeus University.
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Conference paper (peer-reviewed)abstract
- Begreppet estetiska lärprocesser är i viss mån etablerat inom forskning men framförallt inom högskolans pedagogiska praktik. Begreppet är dock svårhanterligt och för lite utforskat med pragmatisk konsekvens för en skolkontext. Musik som estetik associeras exempelvis med sinnlighet och de sköna konsterna, vilket riskerar attbli en skön anakronism när utbildningen rationaliseras och marknadsanpassas. Estetik på traditionell grund har framförallt en funktion som symboliskt språk där människor får syn på sig själva. Denna funktion har fortfarande stor betydelse i en lärarutbildning som vill skapa plats för upplevelser och personlig utveckling för de kommande eleverna och barnen i förskolan. Jag ser dock ett behov av att utvidga musikämnet för barn och ungdomar mot en pragmatisk och samtida inriktning.Det som föregår begreppskonstruktionen (musisk-motorisk) i fråga, är det nya intresse för musik-och idrottsämnet som uppmärksammas av hjärnforskare (se exempelvis Klingberg, 2014). Av denna forskning framlyfts musikaliska aktiviteter som främjar finmotorik och grovmotorik som grund för lärande. Försök görs från hjärnforskningens sida att applicera dessa nya rön i pedagogisk teoribildning,men detta senare fält måste närma sig dessa ofta välfinansierade forskningsrön utifrån sin egen begreppsbildning. Det är därför intressant att från en pedagogisk horisont närma sig hjärnforskningens resultat i ett musikpedagogiskt/pedagogiskt sammanhang. Begreppet ”musisk-motoriska lärprocesser” visar exempelvis hur aktiviteter integrerar motorisk kunskap i kroppen och lägger grund för kognition. Pedagogikämnet står idag och identifierar sig mot större begreppsbildningar som utbildningsvetenskap, men är självt till sin natur tvärvetenskapligt med ursprung inom bland annat inlärningsteori, socialpsykologi samt utvecklingspsykologi.Jag ser det därför som angeläget att diskutera hur pedagogiken håller sig fortsatt tvärvetenskaplig mot nya områden: i vår tid mot hjärnforskning som undersöker musikens funktion som grundläggande för högre kognition, och att vi sätter pedagogiskt fokus på aktiviteter som har värde för barns kognitiva, sociala och fysiska utveckling. Detta bör tydligt ta plats i lärarutbildningens musikundervisning, framförallt mot yngre barn, genom vetenskapliggörande som är rykande aktuellt och angeläget för en utvidgad förståelse för ämnets betydelse i barns utveckling.
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| 8. |
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| 9. |
- Linge, Anna, 1964-
(author)
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Creative Musical Practice in an Educational Context
- 2015
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In: Contemporary approaches to activity theory. - Hershey : IGI Global. - 9781466666030 - 146666603X - 9781466666047 ; , s. 143-160
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Book chapter (other academic/artistic)abstract
- This chapter is based on the author's doctoral thesis. She provides an account of a project on creativity in music education, more specifically a musical classroom for developing creativity. The aim of the study is to find examples or mechanisms of creative pedagogy. This study complements the current tradition for studying methods in teaching and learning music. Creative, prescriptive, and communicative designs of teaching and learning interact during sessions of music making. The empirical findings enable a discussion of the conditions that define creative music making as art and/or play as a socio-cultural activity.
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| 10. |
- Linge, Anna, 1964-
(author)
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Creativity through digital tools in the school-subject of music
- 2021
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In: NOFA-8, The 8th Nordic Conference on Subject Education. - : Western Norway University of Applied Sciences. ; , s. 151-151
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Conference paper (peer-reviewed)abstract
- Introduction. The music subject in schools is currently undergoing a transformation through access to digital tools that allow students to compose and arrange music without prior instrumental knowledge. The digital tools are in the coming curriculum equated with the previous musical instrument, and offer a unified platform for creative creation and recreation.Background. By learning different tools, different ways of communicating are offered and different content comes with the tool inquestion. In a music didactic context, the content to be learned is closely associated with the need of mastering the specific tools. In comparison with a more writing-based school subject, the textbook usually constitutes a content. The students then don´t need to mastering new tools as literacy. As a music teacher, you are faced with the choice of choosing tools that has potential for rich content and understanding of musical symbols and building-blocks. The curriculum (Lgr11), in this case regarding school years 7-9, states three main areas of goals in the subject of music, which are respectively about creating and making music, learning the tools and concepts and putting music in a context. If students have to choose between several different meaningful tools, less time is given to engage themselves in the music's symbols, genre and subject-specific concepts. Traditional musical instruments are complicated tools, not least because they require students’ practice to be able to be used with fluency.Method. In interviews with a teacher who are at the forefront of transformed teaching, qualitative patterns emerge that explain the function of digital tools of music in school. The aim is to discuss the importance of choosing an entrance in music education that is close to the students' pre-understanding and that increases their knowledge of the music's content.
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