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| 2. |
- Soares, Francisco M., et al.
(author)
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Monolithic InP 100-Channel X 10-GHz Device for Optical Arbitrary Waveform Generation
- 2011
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In: IEEE Photonics Journal. - 1943-0655. ; 3:6, s. 975-985
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Journal article (peer-reviewed)abstract
- We demonstrate monolithic integration of a 100-channel arrayed-waveguide grating (AWG) with 10-GHz channel spacing and 100 optically controlled Michelson-interferometer-based phase and amplitude modulators. The high-resolution AWG showed better than -15-dB crosstalk, and the modulator extinction ratio was better than 20 dB with either electrical or optical modulation control. The twin-integrated devices comprise a 50-mm diameter InP wafer with 1200 independent optoelectronic components.
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| 4. |
- Yoo, S. J. B., et al.
(author)
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Spectral phase encoded time spread optical code division multiple access technology for next generation communication networks Invited
- 2007
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In: Journal of Optical Networking. - 1536-5379. ; 6:10, s. 1210-1227
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Journal article (peer-reviewed)abstract
- We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/s (32-user x 10 Gbit/s) all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral efficiency at 100% and above. In particular, InP-based integrated photonics allows implementation of SPECTS O-CDMA transmitters and receivers monolithically integrated on a chip. The integrated InP chip technology not only allows robust and compact configurations for practical and low-cost O-CDMA network deployments but also offers code reconfigurations at rapid rates for secure communication applications.
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| 5. |
- Chen, Tzu‐Yin, et al.
(author)
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Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech‐Derived Peptides on Binding and Inhibitory Activity Against Thrombin
- 2024
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In: ChemBioChem. - : Wiley. - 1439-4227 .- 1439-7633. ; 25:3
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Journal article (peer-reviewed)abstract
- Hirudins, natural sulfo(glyco)proteins, are clinical anticoagulants that directly inhibit thrombin, a key coagulation factor. Their potent thrombin inhibition primarily results from antagonistic interactions with both the catalytic and non-catalytic sites of thrombin. Hirudins often feature sulfate moieties on Tyr residues in their anionic C-terminus region, enabling strong interactions with thrombin exosite-I and effectively blocking its engagement with fibrinogen. Although sulfotyrosines have been identified in various hirudin variants, the precise relationship between sulfotyrosine and the number of negatively charged amino acids within the anionic-rich C-terminus peptide domain for the binding of thrombin has remained elusive. By using Fmoc-SPPS, hirudin dodecapeptides homologous to the C-terminus of hirudin variants from various leech species were successfully synthesized, and the effect of sulfotyrosine and the number of negatively charged amino acids on hirudin-thrombin interactions was investigated. Our findings did not reveal any synergistic effect between an increasing number of sulfotyrosines or negatively charged amino acids and their inhibitory activity on thrombin or fibrinolysis in the assays, despite a higher binding level toward thrombin in the sulfated dodecapeptide Hnip_Hirudin was observed in SPR analysis.
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| 6. |
- Li, Jing, et al.
(author)
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Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce
- 2022
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In: Carbohydrate Research. - : Elsevier BV. - 0008-6215 .- 1873-426X. ; 521
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Journal article (peer-reviewed)abstract
- Polygonatum odoratum is a perennial rhizomatous medicinal plant and different plant parts have been used in the treatment of various ailments. Herein, we have investigated the structural compositions of rhizome, leaf, and stem cell walls. We found 30–44% of polysaccharides in these wall preparations were cyclohexanediaminetetraacetic acid (CDTA) extractable, the proportion of heteromannans (HMs) in the rhizome is nearly three-fold compared to that of the leave and stem. The pectic polysaccharides of the rhizome are also structurally more diverse, with arabinans and type I and type II arabinogalactans being richest as shown by linkage study of the sodium carbonate (Na2CO3) extract. In addition, the 2-linked Araf was rhizome-specific, suggesting the cell walls in the rhizome had adapted to a more complex structure compared to that of the leaf and stem. Water-soluble polysaccharide fractions were also investigated, high proportion of Man as in 4-linked Manp indicated high proportion of HMs. The 21.4 kDa pectic polysaccharides and HMs derived from rhizome cell walls induced specific immune response in mice macrophage cells producing IL-1α and hematopoietic growth factors GM-CSF and G-CSF in vitro.
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| 7. |
- Takano, Y., et al.
(author)
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The single-scattering properties of black carbon aggregates determined from the geometric-optics surface-wave approach and the T-matrix method
- 2013
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In: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0022-4073. ; 125, s. 51-56
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Journal article (peer-reviewed)abstract
- The single-scattering properties of eight black carbon (BC, soot) fractal aggregates, composed of primary spheres from 7 to 600, computed by the geometric-optics surface-wave (GOS) approach coupled with the Rayleigh-Gans-Debye (RGD) adjustment for size parameters smaller than approximately 2, are compared with those determined from the superposition T-matrix method. We show that under the condition of random orientation, the results from GOS/RGD are in general agreement with those from T-matrix in terms of the extinction and absorption cross-sections, the single-scattering co-albedo, and the asymmetry factor. When compared with the specific absorption (m(2)/g) measured in the laboratory, we illustrate that using the observed radii of primary spheres ranging from 3.3 to 25 nm, the theoretical values determined from GOS/RGD for primary sphere numbers of 100-600 are within the range of measured values. The GOS approach can be effectively applied to aggregates composed of a large number of primary spheres (e.g., > 6000) and large size parameters (>> 2) in terms of computational efforts.
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