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  • Shi, TJS, et al. (author)
  • Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain
  • 2008
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 105:50, s. 20004-20008
  • Journal article (peer-reviewed)abstract
    • Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ß3 (PLCß3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Hokfelt, T (1)
Watanabe, M. (1)
Xu, ZQD (1)
Shi, TJS (1)
Hammarberg, H (1)
Liu, SXL (1)
University
Karolinska Institutet (1)
Language
English (1)
Year
2008 (1)

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