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- Ljungkrantz, M, et al.
(author)
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Type 1 diabetes : Increased height and weight gains in early childhood
- 2008
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 9:3 PART 2, s. 50-56
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Journal article (peer-reviewed)abstract
- Objective: The accelerator/beta-cell stress hypothesis regards insulin resistance as one common basis for type 1 and type 2 diabetes and weight increase as an important trigger of type 1 diabetes. To test this hypothesis, we examined children's height and weight gain from birth to the time of diagnosis of type 1 diabetes. Method: Growth charts (n=316) from children 0-16yr old up to the time of diagnosis of type 1 diabetes were compared with growth charts from age- and sex-matched controls. Results: Compared with their controls, children who developed diabetes had experienced more pronounced gain in both weight and height. In the year of diagnosis, they were taller [0.5 vs. 0.36 standard deviation score (SDS), p<0.03] and heavier (0.7 vs. 0.45 SDS, p<0.01). Children who developed diabetes aged 5yr or less gained more weight during the period between their third month and third year of life (p<0.01). Children who were diagnosed between 6 and 10yr of age had gained more in height before they were 5yr old (p<0.05). Regression analysis showed that a high weight or a high body mass index (BMI) at 5yr of age indicated, more than the other measurements, a high risk for diabetes later during childhood, while height and weight at ages less than 5yr did not add any further information on diabetes risk. Conclusions: Rapid growth before 7yr of age and increased BMI in childhood are risk factors for later type 1 diabetes. These findings support the accelerator/beta-cell stress hypothesis. © 2008 The Author Journal compilation © 2008 Blackwell Munksgaard.
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| 3. |
- Rodriguez-Navas, Guillermo, et al.
(author)
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Automated specification and verification of functional safety in heavy-vehicles : The verispec approach
- 2014
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In: Proceedings - Design Automation Conference. - New York, NY, USA : ACM. - 9781479930173
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Conference paper (peer-reviewed)abstract
- ISO 26262 is the new standard for automotive functional safety. This standard identies major process steps across a large number of system stages as well as safety-related artifacts required as input and output of these steps. The VeriSpec project intends to identify the main challenges for the adoption of ISO 26262 by the heavy-vehicle industry and to provide useful and industrially relevant components (methods, tools etc.) required by the standard. The project work targets two main research goals: (i) requirement formalization support, including a usable front-end for specifying requirements by using patterns, and (ii) formal analysis of realizations in form of architectural models at various levels of abstraction, by model-checking the formal representations of the latter. In this paper, we present the current challenges facing industry and justifying VeriSpec, together with a preliminary roadmap for the research.
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